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Research ArticleNew Research, Sensory and Motor Systems

Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray

Vijay K. Samineni, Jose G. Grajales-Reyes, Bryan A. Copits, Daniel E. O’Brien, Sarah L. Trigg, Adrian M. Gomez, Michael R. Bruchas and Robert W. Gereau IV
eNeuro 17 March 2017, 4 (2) ENEURO.0129-16.2017; DOI: https://doi.org/10.1523/ENEURO.0129-16.2017
Vijay K. Samineni
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Jose G. Grajales-Reyes
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
2Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110
3Division of Biomedical and Biological Sciences Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Bryan A. Copits
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Daniel E. O’Brien
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
3Division of Biomedical and Biological Sciences Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Sarah L. Trigg
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Adrian M. Gomez
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
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Michael R. Bruchas
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
4Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Robert W. Gereau IV
1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
5 Washington University School of Medicine, St. Louis, MO 63110
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0129-16.2017
PubMed 
28374016
Published By 
Society for Neuroscience
History 
  • Received May 20, 2016
  • Revision received March 1, 2017
  • Accepted March 3, 2017
  • Published online March 17, 2017.
Copyright & Usage 
Copyright © 2017 Samineni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Vijay K. Samineni1,5,
  2. Jose G. Grajales-Reyes1,2,3,5,
  3. Bryan A. Copits1,5,
  4. Daniel E. O’Brien1,3,5,
  5. Sarah L. Trigg1,5,
  6. Adrian M. Gomez1,
  7. Michael R. Bruchas1,4,5 and
  8. Robert W. Gereau IV1,5
  1. 1Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110
  2. 2Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110
  3. 3Division of Biomedical and Biological Sciences Graduate Program in Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
  4. 4Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
  5. 5 Washington University School of Medicine, St. Louis, MO 63110
  1. Correspondence should be addressed to Robert W. Gereau IV, Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8054, St. Louis, MO 63110, E-mail: gereaur{at}wustl.edu.
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Author contributions

  1. Author contributions: V.K.S. and R.W.G. designed research; V.K.S., B.A.C., J.G.G.R., and D.E.O. performed research; M.R.B. contributed unpublished reagents/analytic tools; V.K.S., J.G.G.R., B.A.C., R.W.G., A.M.G., and S.L.T. analyzed data; V.K.S. and R.W.G. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • 3 This work was funded by the NIH Director’s Transformative Research Award TR01 NS081707 (to R.W.G. and M.R.B.), the NINDS R01NS048602 (to R.W.G.), Urology Care Foundation Research Scholars Program and Kailash Kedia Research Scholar Award to V.K.S., the NIGMS Training Grant T32 GM108539 (to B.A.C.), and the Medical Scientist Training Program (MSTP) Grant T32GM07200 (to J.G.G.R.).

Funding

  • NIH Director's Transformative Research Award

    TR01 NS081707
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; R01NS048602
  • HHS | NIH | National Institute of General Medical Sciences (NIGMS)

    100000057; T32 GM108539

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Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray
Vijay K. Samineni, Jose G. Grajales-Reyes, Bryan A. Copits, Daniel E. O’Brien, Sarah L. Trigg, Adrian M. Gomez, Michael R. Bruchas, Robert W. Gereau IV
eNeuro 17 March 2017, 4 (2) ENEURO.0129-16.2017; DOI: 10.1523/ENEURO.0129-16.2017

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Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray
Vijay K. Samineni, Jose G. Grajales-Reyes, Bryan A. Copits, Daniel E. O’Brien, Sarah L. Trigg, Adrian M. Gomez, Michael R. Bruchas, Robert W. Gereau IV
eNeuro 17 March 2017, 4 (2) ENEURO.0129-16.2017; DOI: 10.1523/ENEURO.0129-16.2017
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Keywords

  • chemogenetics
  • Descending modulation
  • DREADDs
  • PAG
  • pain
  • RVM

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