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Research ArticleNew Research, Neuronal Excitability

Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors

Michael R. Post, Gabrielle S. Tender, Henry A. Lester and Dennis A. Dougherty
eNeuro 17 March 2017, 4 (2) ENEURO.0032-17.2017; https://doi.org/10.1523/ENEURO.0032-17.2017
Michael R. Post
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
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Gabrielle S. Tender
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
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Henry A. Lester
2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
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Dennis A. Dougherty
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0032-17.2017
PubMed 
28589175
Published By 
Society for Neuroscience
History 
  • Received January 26, 2017
  • Revision received February 28, 2017
  • Accepted March 2, 2017
  • Published online March 17, 2017.
Copyright & Usage 
Copyright © 2017 Post et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Michael R. Post1,
  2. Gabrielle S. Tender1,
  3. Henry A. Lester2 and
  4. Dennis A. Dougherty1
  1. 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125
  2. 2Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
  1. Correspondence should be addressed to Dennis A. Dougherty, California Institute of Technology, MC 164-30, 1200 East California Boulevard, Pasadena, CA 91125. E-mail: dadoc{at}caltech.edu.
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Author contributions

  1. Author contributions: M.R.P., G.S.T., H.A.L., and D.A.D. designed research; M.R.P. and G.S.T. performed research; M.R.P. and G.S.T. analyzed data; M.R.P. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) (100000065, Grant NS34407); HHS | NIH | National Institute on Drug Abuse (NIDA) (Funding 100000026, Grand DA 019375); and by Beckman Institute at Caltech. M.R.P. was supported by the NIH/NRSA Training Grant 5 T32 GM07616.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; NS34407
  • HHS | NIH | National Institute on Drug Abuse (NIDA)

    100000026; DA 019375

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  • You are viewing the most recent version of this article.
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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors
Michael R. Post, Gabrielle S. Tender, Henry A. Lester, Dennis A. Dougherty
eNeuro 17 March 2017, 4 (2) ENEURO.0032-17.2017; DOI: 10.1523/ENEURO.0032-17.2017

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Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors
Michael R. Post, Gabrielle S. Tender, Henry A. Lester, Dennis A. Dougherty
eNeuro 17 March 2017, 4 (2) ENEURO.0032-17.2017; DOI: 10.1523/ENEURO.0032-17.2017
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Keywords

  • Parkinson's disease
  • addiction
  • ion channels
  • nicotinic acetylcholine receptors
  • electrophysiology
  • Non-canonical amino acids

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