Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

Yulan Xiong; Stewart Neifert; Senthilkumar S. Karuppagounder; Jeannette N. Stankowski; Byoung Dae Lee; Jonathan C. Grima; Guanxing Chen; Han Seok Ko; Yunjong Lee; Debbie Swing; Lino Tessarollo; Ted M. Dawson; Valina L. Dawson

doi:10.1523/ENEURO.0004-17.2017

Research ArticleNew Research, Disorders of the Nervous System

Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Jeannette N. Stankowski, Byoung Dae Lee, Jonathan C. Grima, Guanxing Chen, Han Seok Ko, Yunjong Lee, Debbie Swing, Lino Tessarollo, Ted M. Dawson and Valina L. Dawson

eNeuro 6 March 2017, 4 (2) ENEURO.0004-17.2017; https://doi.org/10.1523/ENEURO.0004-17.2017

Yulan Xiong

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

8Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas 66506

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Stewart Neifert

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Senthilkumar S. Karuppagounder

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Jeannette N. Stankowski

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Byoung Dae Lee

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Jonathan C. Grima

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Soloman H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Guanxing Chen

8Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas 66506

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Han Seok Ko

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Yunjong Lee

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Debbie Swing

9Neural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702

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Lino Tessarollo

9Neural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702

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Ted M. Dawson

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Soloman H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

5Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

6Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130

7Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130

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Valina L. Dawson

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Soloman H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

4Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

6Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130

7Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130

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Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

eNeuro 6 March 2017, 4 (2) ENEURO.0004-17.2017; DOI: 10.1523/ENEURO.0004-17.2017

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Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

eNeuro 6 March 2017, 4 (2) ENEURO.0004-17.2017; DOI: 10.1523/ENEURO.0004-17.2017

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Parkinson’s disease
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transgenic mice
α-synuclein

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Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

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