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Research ArticleNew Research, Disorders of the Nervous System

GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome

D. Sinclair, R. Featherstone, M. Naschek, J. Nam, A. Du, S. Wright, K. Pance, O. Melnychenko, R. Weger, S. Akuzawa, M. Matsumoto and S. J. Siegel
eNeuro 17 February 2017, 4 (1) ENEURO.0380-16.2017; https://doi.org/10.1523/ENEURO.0380-16.2017
D. Sinclair
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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R. Featherstone
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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M. Naschek
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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J. Nam
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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A. Du
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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S. Wright
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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K. Pance
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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  • ORCID record for K. Pance
O. Melnychenko
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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R. Weger
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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S. Akuzawa
2Neuroscience Research Unit, DDR, Astellas Pharma Inc., Tsukuba-Shi, Ibaraki 305-8585, Japan
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M. Matsumoto
2Neuroscience Research Unit, DDR, Astellas Pharma Inc., Tsukuba-Shi, Ibaraki 305-8585, Japan
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S. J. Siegel
1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0380-16.2017
PubMed 
28451631
Published By 
Society for Neuroscience
History 
  • Received December 20, 2016
  • Revision received February 9, 2017
  • Accepted February 13, 2017
  • Published online February 17, 2017.
Copyright & Usage 
Copyright © 2017 Sinclair et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. D. Sinclair1,
  2. R. Featherstone1,
  3. M. Naschek1,
  4. J. Nam1,
  5. A. Du1,
  6. S. Wright1,
  7. K. Pance1,
  8. O. Melnychenko1,
  9. R. Weger1,
  10. S. Akuzawa2,
  11. M. Matsumoto2 and
  12. S. J. Siegel1
  1. 1Translational Neuroscience Program Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
  2. 2Neuroscience Research Unit, DDR, Astellas Pharma Inc., Tsukuba-Shi, Ibaraki 305-8585, Japan
  1. Correspondence should be addressed to either of the following: Steven J Siegel, Department of Psychiatry and Behavioral Science, University of Southern California, 2250 Alcazar St, Ste 2200, Los Angeles, CA 90033. E-mail: siegels{at}usc.edu; or Duncan Sinclair, Wicking Centre, University of Tasmania, Private Bag 143, Hobart, TAS 7001, Australia. E-mail: duncan.sinclair{at}utas.edu.au.
  • D. Sinclair’s present address: Wicking Centre, University of Tasmania, Private Bag 143, Hobart, TAS 7001, Australia; R. Featherstone’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033; O. Melnychenko’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033; S. J. Siegel’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033.

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Author contributions

  1. Author contributions: D.S., R.F., S.A., M.M., and S.J.S. designed research; D.S., R.F., M.N., J.N., A.D., S.W., K.P., O.M., and R.W. performed research; D.S., R.F., M.N., J.N., A.D., S.W., K.P., O.M., R.W., and S.J.S. analyzed data; D.S., R.F., and S.J.S. wrote the paper.

  • D. Sinclair’s present address: Wicking Centre, University of Tasmania, Private Bag 143, Hobart, TAS 7001, Australia; R. Featherstone’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033; O. Melnychenko’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033; S. J. Siegel’s present address: Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA 90033.

Disclosures

  • SJS is a consultant to, and receives grant support from, Astellas Pharma Inc., Zynerba Pharmaceuticals, and Boehringer Ingleheim. SA and MM are full-time employees of Astellas Pharma Inc. All other authors declare no competing financial interests.

  • Department of Health | National Health and Medical Research Council (NHMRC) [APP1072878]; Astellas Pharma (Astellas).

Funding

  • Department of Health | National Health and Medical Research Council (NHMRC)

    501100000925; APP1072878
  • Astellas Pharma (Astellas)

    501100004948

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Apr 2017022
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GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome
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GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome
D. Sinclair, R. Featherstone, M. Naschek, J. Nam, A. Du, S. Wright, K. Pance, O. Melnychenko, R. Weger, S. Akuzawa, M. Matsumoto, S. J. Siegel
eNeuro 17 February 2017, 4 (1) ENEURO.0380-16.2017; DOI: 10.1523/ENEURO.0380-16.2017

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GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome
D. Sinclair, R. Featherstone, M. Naschek, J. Nam, A. Du, S. Wright, K. Pance, O. Melnychenko, R. Weger, S. Akuzawa, M. Matsumoto, S. J. Siegel
eNeuro 17 February 2017, 4 (1) ENEURO.0380-16.2017; DOI: 10.1523/ENEURO.0380-16.2017
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Keywords

  • EEG
  • fragile X syndrome
  • GABA
  • gamma
  • Racemic Baclofen
  • working memory

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