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Research ArticleNew Research, Cognition and Behavior

Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation

Yili Zhang, Paul Smolen, Douglas A. Baxter and John H. Byrne
eNeuro 26 January 2017, 4 (1) ENEURO.0373-16.2017; https://doi.org/10.1523/ENEURO.0373-16.2017
Yili Zhang
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
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Paul Smolen
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
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Douglas A. Baxter
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
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John H. Byrne
Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0373-16.2017
PubMed 
28197555
Published By 
Society for Neuroscience
History 
  • Received December 15, 2016
  • Revision received January 13, 2017
  • Accepted January 19, 2017
  • Published online January 26, 2017.
Copyright & Usage 
Copyright © 2017 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yili Zhang,
  2. Paul Smolen,
  3. Douglas A. Baxter and
  4. John H. Byrne
  1. Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030
  1. Correspondence should be addressed to John H. Byrne, Ph.D., Department of Neurobiology and Anatomy, W.M. Keck Center for the Neurobiology of Learning and Memory, McGovern Medical School, Houston, TX 77030. E-mail: John.H.Byrne{at}uth.tmc.edu.
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Author contributions

  1. Y.Z. performed the immunofluorescence experiments, implemented the computational model and ran all simulations. P.S. and D.A.B. helped design and supervise the empirical and computational studies. J.H.B. supervised and contributed to all aspects of these studies. All authors discussed the results and contributed to the writing and editing of the manuscript.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by NIH Grants NS019895 and NS073974.

Funding

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; NS019895
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; NS073974

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  • You are viewing the most recent version of this article.
  • previous version (January 26, 2017).

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Total 202440620138
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Total 2025426154
Total80546711178
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Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation
Yili Zhang, Paul Smolen, Douglas A. Baxter, John H. Byrne
eNeuro 26 January 2017, 4 (1) ENEURO.0373-16.2017; DOI: 10.1523/ENEURO.0373-16.2017

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Biphasic Regulation of p38 MAPK by Serotonin Contributes to the Efficacy of Stimulus Protocols That Induce Long-Term Synaptic Facilitation
Yili Zhang, Paul Smolen, Douglas A. Baxter, John H. Byrne
eNeuro 26 January 2017, 4 (1) ENEURO.0373-16.2017; DOI: 10.1523/ENEURO.0373-16.2017
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Keywords

  • biphasic regulation
  • computational model
  • ERK
  • LTF
  • p38 MAPK
  • spaced stimulation

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