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Research ArticleNew Research, Disorders of the Nervous System

Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model

Tanya S. McDonald, Catalina Carrasco-Pozo, Mark P. Hodson and Karin Borges
eNeuro 10 February 2017, 4 (1) ENEURO.0341-16.2017; DOI: https://doi.org/10.1523/ENEURO.0341-16.2017
Tanya S. McDonald
1Department of Pharmacology, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia
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Catalina Carrasco-Pozo
1Department of Pharmacology, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia
2Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
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Mark P. Hodson
2Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
3Metabolomics Australia, Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, St. Lucia, QLD 4072, Australia
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Karin Borges
1Department of Pharmacology, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0341-16.2017
PubMed 
28303258
Published By 
Society for Neuroscience
History 
  • Received November 14, 2016
  • Revision received January 10, 2017
  • Accepted January 16, 2017
  • Published online February 10, 2017.
Copyright & Usage 
Copyright © 2017 McDonald et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tanya S. McDonald1,
  2. Catalina Carrasco-Pozo1,2,
  3. Mark P. Hodson2,3 and
  4. Karin Borges1
  1. 1Department of Pharmacology, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia
  2. 2Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
  3. 3Metabolomics Australia, Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, St. Lucia, QLD 4072, Australia
  4. 4School of Pharmacy, the University of Queensland, QLD 4072, St. Lucia, QLD 4072, Australia
  1. Correspondence should be addressed to Tanya S. McDonald, Department of Pharmacology, School of Biomedical Sciences, Skerman Building 65, St Lucia, QLD 4072, Australia. E-mail: tanya.mcdonald{at}uqconnect.edu.au.
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Author contributions

  1. Author contributions: T.S.M. and K.B. designed research; T.S.M., C.C.-P., and M.P.H. performed research; T.S.M., C.C.-P., and M.P.H. analyzed data; T.S.M., C.C.-P., M.P.H., and K.B. wrote the paper.

Disclosures

  • Authors report no conflict of interest

  • Department of Health, National Health and Medical Research Council (NHMRC) 1044007 to K.B.; Fondecyt Initiation into Research Grant 11130232 to C.C.-P.; APA Scholarship to T.S.M.

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Mar 201705020
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Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model
Tanya S. McDonald, Catalina Carrasco-Pozo, Mark P. Hodson, Karin Borges
eNeuro 10 February 2017, 4 (1) ENEURO.0341-16.2017; DOI: 10.1523/ENEURO.0341-16.2017

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Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model
Tanya S. McDonald, Catalina Carrasco-Pozo, Mark P. Hodson, Karin Borges
eNeuro 10 February 2017, 4 (1) ENEURO.0341-16.2017; DOI: 10.1523/ENEURO.0341-16.2017
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Keywords

  • glucose
  • Glycolysis
  • metabolism
  • mitochondria
  • seizure
  • TCA cycle

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