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Research ArticleFailure to Replicate, Sensory and Motor Systems

Experimental Design and Data Analysis Issues Contribute to Inconsistent Results of C-Bouton Changes in Amyotrophic Lateral Sclerosis

S. Shekar Dukkipati, Aouatef Chihi, Yiwen Wang and Sherif M. Elbasiouny
eNeuro 6 January 2017, 4 (1) ENEURO.0281-16.2016; DOI: https://doi.org/10.1523/ENEURO.0281-16.2016
S. Shekar Dukkipati
1Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, Ohio 45435
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Aouatef Chihi
2Department of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, Ohio 45435
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Yiwen Wang
2Department of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, Ohio 45435
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Sherif M. Elbasiouny
1Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, Ohio 45435
2Department of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, Ohio 45435
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0281-16.2016
PubMed 
28101533
Published By 
Society for Neuroscience
History 
  • Received September 14, 2016
  • Revision received November 23, 2016
  • Accepted December 26, 2016
  • Published online January 6, 2017.
Copyright & Usage 
Copyright © 2017 Dukkipati et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. S. Shekar Dukkipati1,
  2. Aouatef Chihi2,
  3. Yiwen Wang2 and
  4. Sherif M. Elbasiouny1,2
  1. 1Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, Ohio 45435
  2. 2Department of Biomedical, Industrial, and Human Factors Engineering, College of Engineering and Computer Science, Wright State University, Dayton, Ohio 45435
  1. Correspondence should be addressed to Dr. Sherif M. Elbasiouny, 3640 Colonel Glenn Highway, Dayton, OH 45435. E-mail: sherif.elbasiouny{at}wright.edu.
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Author contributions

  1. Author contributions: S.S.D. and S.M.E. designed research; S.S.D., A.C., and Y.W. performed research; S.S.D. analyzed data; S.S.D. and S.M.E. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This project was funded by National Institutes of Health Grant NS091836. A.C. was supported through the NIH/NIGMS R25GM090122, IMSD BioSTAR program grant at Wright State University.

Funding

  • NIH-NINDS

    NS091836

Other Version

  • previous version (January 06, 2017).
  • You are viewing the most recent version of this article.

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Jan 201734998166
Feb 20173110045
Mar 20176717236
Apr 2017597324
May 2017405522
Jun 2017394016
Jul 2017273629
Aug 2017274145
Sep 2017326850
Oct 2017384228
Nov 20174214335
Dec 2017315798
Total 20177821447504
Jan 2018194678
Feb 2018184810
Mar 2018214312
Apr 2018195327
May 2018234915
Jun 2018205341
Jul 201824388
Aug 2018154824
Sep 201812503
Oct 20181212311
Nov 2018171445
Dec 2018111256
Total 20182111241170
Jan 2019121223
Feb 20191413212
Mar 201941175
Apr 2019104310
May 201932112
Jun 201984220
Jul 201983817
Aug 201942410
Sep 201951216
Oct 20195127
Nov 20198217
Dec 20192139
Total 201983597128
Jan 2020564
Feb 202001211
Mar 2020477
Apr 20203115
May 20203206
Jun 2020183
Jul 20208245
Aug 20201104
Sep 202064015
Oct 2020124711
Nov 202024314
Dec 202046915
Total 202049297100
Jan 202155923
Feb 20213396
Mar 2021010
Total 202189929
Total11333681931
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Experimental Design and Data Analysis Issues Contribute to Inconsistent Results of C-Bouton Changes in Amyotrophic Lateral Sclerosis
S. Shekar Dukkipati, Aouatef Chihi, Yiwen Wang, Sherif M. Elbasiouny
eNeuro 6 January 2017, 4 (1) ENEURO.0281-16.2016; DOI: 10.1523/ENEURO.0281-16.2016

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Experimental Design and Data Analysis Issues Contribute to Inconsistent Results of C-Bouton Changes in Amyotrophic Lateral Sclerosis
S. Shekar Dukkipati, Aouatef Chihi, Yiwen Wang, Sherif M. Elbasiouny
eNeuro 6 January 2017, 4 (1) ENEURO.0281-16.2016; DOI: 10.1523/ENEURO.0281-16.2016
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Keywords

  • ALS
  • amyotrophic lateral sclerosis
  • C-bouton
  • cholinergic synapse
  • motoneuron
  • SOD1-G93A

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