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Research ArticleNew Research, Novel Tools and Methods

Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy

Yikun Li, Eric B. Dammer, Xiaohui Zhang-Brotzge, Scott Chen, Duc M. Duong, Nicholas T. Seyfried, Chia-Yi Kuan and Yu-Yo Sun
eNeuro 4 January 2017, 4 (1) ENEURO.0253-16.2016; https://doi.org/10.1523/ENEURO.0253-16.2016
Yikun Li
1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
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Eric B. Dammer
2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
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Xiaohui Zhang-Brotzge
1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
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Scott Chen
1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
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Duc M. Duong
2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
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Nicholas T. Seyfried
2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
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Chia-Yi Kuan
1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
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Yu-Yo Sun
1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0253-16.2016
PubMed 
28101531
Published By 
Society for Neuroscience
History 
  • Received August 25, 2016
  • Revision received December 10, 2016
  • Accepted December 22, 2016
  • Published online January 4, 2017.
Copyright & Usage 
Copyright © 2017 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Yikun Li1,
  2. Eric B. Dammer2,
  3. Xiaohui Zhang-Brotzge1,
  4. Scott Chen1,
  5. Duc M. Duong2,
  6. Nicholas T. Seyfried2,
  7. Chia-Yi Kuan1 and
  8. Yu-Yo Sun1
  1. 1Department of Pediatrics, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, GA 30322
  2. 2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322
  1. Correspondence should be addressed to Chia-Yi Kuan, Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Health Science Research Building E470, 1760 Haygood Drive, Atlanta, GA 30322. E-mail: alex.kuan{at}emory.edu; or Yu-Yo Sun, Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Health Science Research Building E470, 1760 Haygood Drive, Atlanta, GA 30322. E-mail: yuyosun42{at}emory.edu.
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Author contributions

  1. Author contributions: Y.L., E.B.D., X.Z.-B., S.C., and D.M.D. performed experiments and analyzed data. N.T.S., C.-Y.K. and Y.-Y.S. designed experiments, analyzed data, and wrote the manuscript.

Disclosures

  • Authors report no conflict of interest.

  • This work was supported by NIH grants (NS084744, HD080429, NS095064 to C.-Y.K.) and an American Heart Association fellowship (to Y.-Y.S.) and supported in part by the Proteomics Core of the Emory Neuroscience NINDS Core Facilities grant (P30NS055077).

Funding

  • HHS | NIH | National Institute of Child Health and Human Development (NICHD)

    100000071; HD080429
  • NINDS

    NS084744
  • NINDS

    NS095064
  • American Heart Association (AHA)

    100000968; 4POST18720029
  • NINDS

    P30NS055077

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  • You are viewing the most recent version of this article.
  • previous version (January 04, 2017).

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Apr 2017244153
May 2017122828
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Jul 2017103333
Aug 2017624840
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Feb 2018343813
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Feb 202044940
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Feb 20211417
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Jan 202554918
Feb 202537320
Mar 202577840
Apr 202514417
May 202535618
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Total 202521335121
Total97359302084
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Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy
Yikun Li, Eric B. Dammer, Xiaohui Zhang-Brotzge, Scott Chen, Duc M. Duong, Nicholas T. Seyfried, Chia-Yi Kuan, Yu-Yo Sun
eNeuro 4 January 2017, 4 (1) ENEURO.0253-16.2016; DOI: 10.1523/ENEURO.0253-16.2016

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Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy
Yikun Li, Eric B. Dammer, Xiaohui Zhang-Brotzge, Scott Chen, Duc M. Duong, Nicholas T. Seyfried, Chia-Yi Kuan, Yu-Yo Sun
eNeuro 4 January 2017, 4 (1) ENEURO.0253-16.2016; DOI: 10.1523/ENEURO.0253-16.2016
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Keywords

  • HIE
  • hypoxia-ischemia
  • LC-MS/MS

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