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Research ArticleNew Research, Disorders of the Nervous System

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome

Rahul Gupta, Matthews Lan, Jelena Mojsilovic-Petrovic, Won Hoon Choi, Nathaniel Safren, Sami Barmada, Min Jae Lee and Robert Kalb
eNeuro 24 January 2017, 4 (1) ENEURO.0249-16.2017; https://doi.org/10.1523/ENEURO.0249-16.2017
Rahul Gupta
1Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, 19104
2Department of Biology, College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104
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Matthews Lan
3Department of Biochemistry, College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, 19104
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Jelena Mojsilovic-Petrovic
4Division of Neurology, Department of Pediatrics, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104
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Won Hoon Choi
5Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
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Nathaniel Safren
6Department of Neurology, University of Michigan, Ann Arbor, MI, 48109
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Sami Barmada
6Department of Neurology, University of Michigan, Ann Arbor, MI, 48109
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Min Jae Lee
5Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
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Robert Kalb
4Division of Neurology, Department of Pediatrics, Research Institute, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104
7Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104
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eneuro: 4 (1)
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January/February 2017
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The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome
Rahul Gupta, Matthews Lan, Jelena Mojsilovic-Petrovic, Won Hoon Choi, Nathaniel Safren, Sami Barmada, Min Jae Lee, Robert Kalb
eNeuro 24 January 2017, 4 (1) ENEURO.0249-16.2017; DOI: 10.1523/ENEURO.0249-16.2017

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The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome
Rahul Gupta, Matthews Lan, Jelena Mojsilovic-Petrovic, Won Hoon Choi, Nathaniel Safren, Sami Barmada, Min Jae Lee, Robert Kalb
eNeuro 24 January 2017, 4 (1) ENEURO.0249-16.2017; DOI: 10.1523/ENEURO.0249-16.2017
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Keywords

  • ALS
  • Frontotemporal Dementia
  • lysosome-autophagy
  • motor neuron
  • proteasome

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