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Research ArticleNew Research, Integrative Systems

GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance

Kristy M. Heppner, Arian F. Baquero, Camdin M. Bennett, Sarah R. Lindsley, Melissa A. Kirigiti, Baylin Bennett, Martha A. Bosch, Aaron J. Mercer, Oline K. Rønnekleiv, Cadence True, Kevin L. Grove and M. Susan Smith
eNeuro 5 January 2017, 4 (1) ENEURO.0198-16.2016; DOI: https://doi.org/10.1523/ENEURO.0198-16.2016
Kristy M. Heppner
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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Arian F. Baquero
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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Camdin M. Bennett
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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  • ORCID record for Camdin M. Bennett
Sarah R. Lindsley
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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  • ORCID record for Sarah R. Lindsley
Melissa A. Kirigiti
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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  • ORCID record for Melissa A. Kirigiti
Baylin Bennett
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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  • ORCID record for Baylin Bennett
Martha A. Bosch
2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, 97239
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  • ORCID record for Martha A. Bosch
Aaron J. Mercer
3Novo Nordisk Research Center, Seattle, WA 98109
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  • ORCID record for Aaron J. Mercer
Oline K. Rønnekleiv
2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, 97239
4Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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Cadence True
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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Kevin L. Grove
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
3Novo Nordisk Research Center, Seattle, WA 98109
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M. Susan Smith
1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, 97239
4Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0198-16.2016
PubMed 
28144621
Published By 
Society for Neuroscience
History 
  • Received July 11, 2016
  • Revision received November 28, 2016
  • Accepted December 21, 2016
  • Published online January 5, 2017.
Copyright & Usage 
Copyright © 2017 Heppner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Kristy M. Heppner1,
  2. Arian F. Baquero1,
  3. Camdin M. Bennett1,
  4. Sarah R. Lindsley1,
  5. Melissa A. Kirigiti1,
  6. Baylin Bennett1,
  7. Martha A. Bosch2,
  8. Aaron J. Mercer3,
  9. Oline K. Rønnekleiv2,4,
  10. Cadence True1,
  11. Kevin L. Grove1,3 and
  12. M. Susan Smith1,2,4
  1. 1Division of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
  2. 2Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, 97239
  3. 3Novo Nordisk Research Center, Seattle, WA 98109
  4. 4Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006
  1. Correspondence should be addressed to M. Susan Smith, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006. E-mail: smithsu{at}ohsu.edu.
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Author contributions

  1. Author contributions: KMH was responsible for data collection, study conception and design, data analysis and interpretation, and writing of the manuscript. AFB, CB, SRL, MAK, BB, MAB, CT, AJM, and OKR collected, analyzed, and interpreted data. AFB, OKR, MSS, and KLG advised on study concept and design as well as critical revision of the manuscript.

Disclosures

  • KMH, AFB, CB, AJM, and KLG are full-time employees of Novo Nordisk, which markets liraglutide for the treatment of type 2 diabetes mellitus and obesity. SRL, MAK, BB, MAB, OKR, CT, and MSS have nothing to disclose.

  • The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core is supported by the Eunice Kennedy Shriver NICHD/NIH (NCTRI) Grant P50-HD28934. KMH received funding from the Collins Medical Trust. NIH grants that supported this work are HD014643, DK068098, P51 OD011092.

Funding

  • Collins Medical Trust

    100002028
  • NIH

    P51 OD011092
  • NIH

    HD014643
  • NIH

    DK068098

Other Version

  • previous version (January 05, 2017).
  • You are viewing the most recent version of this article.

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Jan 201751451229
Feb 201754177128
Mar 20176427257
Apr 2017769668
May 2017787236
Jun 2017425534
Jul 2017394239
Aug 2017224336
Sep 2017234022
Oct 2017345436
Nov 2017408030
Dec 201729308
Total 201710151012723
Jan 2018293413
Feb 201816255
Mar 201826477
Apr 2018255223
May 2018174014
Jun 2018295621
Jul 2018213613
Aug 2018226128
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Total 2018305561186
Jan 201914716
Feb 2019201149
Mar 201931886
Apr 2019818612
May 2019614316
Jun 2019109418
Jul 2019418717
Aug 20191025715
Sep 2019326317
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Dec 2019611910
Total 2019942042147
Jan 20205249
Feb 202032011
Mar 20200135
Apr 20201145
May 20202254
Jun 20202538
Jul 202026514
Aug 20202313
Sep 202035712
Oct 20204898
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Dec 2020410410
Total 202031578104
Jan 202126211
Feb 202135017
Mar 2021210518
Apr 202147911
May 20213596
Jun 202115911
Jul 202148435
Aug 20213569
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Total 202128846176
Jan 202216722
Feb 202236416
Mar 202227820
Apr 202214713
May 202214819
Total 2022830490
Total148153431426
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GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance
Kristy M. Heppner, Arian F. Baquero, Camdin M. Bennett, Sarah R. Lindsley, Melissa A. Kirigiti, Baylin Bennett, Martha A. Bosch, Aaron J. Mercer, Oline K. Rønnekleiv, Cadence True, Kevin L. Grove, M. Susan Smith
eNeuro 5 January 2017, 4 (1) ENEURO.0198-16.2016; DOI: 10.1523/ENEURO.0198-16.2016

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GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance
Kristy M. Heppner, Arian F. Baquero, Camdin M. Bennett, Sarah R. Lindsley, Melissa A. Kirigiti, Baylin Bennett, Martha A. Bosch, Aaron J. Mercer, Oline K. Rønnekleiv, Cadence True, Kevin L. Grove, M. Susan Smith
eNeuro 5 January 2017, 4 (1) ENEURO.0198-16.2016; DOI: 10.1523/ENEURO.0198-16.2016
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Keywords

  • fasting
  • GLP-1
  • hypothalamus
  • kisspeptin
  • LH
  • liraglutide

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