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Research ArticleNew Research, Disorders of the Nervous System

Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action

Merja H. Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T. Männistö and Raimo K. Tuominen
eNeuro 22 February 2017, 4 (1) ENEURO.0117-16.2017; DOI: https://doi.org/10.1523/ENEURO.0117-16.2017
Merja H. Voutilainen
1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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  • ORCID record for Merja H. Voutilainen
Francesca De Lorenzo
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Polina Stepanova
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Susanne Bäck
1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Li-Ying Yu
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Päivi Lindholm
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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  • ORCID record for Päivi Lindholm
Eeva Pörsti
1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Mart Saarma
2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Pekka T. Männistö
1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Raimo K. Tuominen
1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0117-16.2017
PubMed 
28303260
Published By 
Society for Neuroscience
History 
  • Received May 12, 2016
  • Revision received February 3, 2017
  • Accepted February 8, 2017
  • Published online February 22, 2017.
Copyright & Usage 
Copyright © 2017 Voutilainen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Merja H. Voutilainen1,2,
  2. Francesca De Lorenzo2,*,
  3. Polina Stepanova2,*,
  4. Susanne Bäck1,
  5. Li-Ying Yu2,
  6. Päivi Lindholm2,
  7. Eeva Pörsti1,
  8. Mart Saarma2,
  9. Pekka T. Männistö1 and
  10. Raimo K. Tuominen1
  1. 1Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
  2. 2Institute of Biotechnology, Viikki Biocenter, University of Helsinki, FIN-00014 Helsinki, Finland
  1. Correspondence should be addressed to Dr. Merja H. Voutilainen, PhD, Institute of Biotechnology, P.O. Box 56, University of Helsinki, FI-00014 Helsinki, Finland. E-mail: merja.h.voutilainen{at}helsinki.fi.
  • S. Bäck’s present address: National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224.

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Author contributions

  1. Author contributions: M.H.V., S.B., M.S., P.T.M., and R.K.T. designed research; M.H.V., F.D.L., P.S., S.B., L.Y., P.L., and E.P. performed research; M.H.V., F.D.L., P.S., S.B., L.Y., P.L., and E.P. analyzed data; M.H.V., M.S., P.T.M., and R.K.T. wrote the paper.

  2. ↵* F.D.L. and P.S. contributed equally to this work.

  • S. Bäck’s present address: National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224.

Disclosures

  • MHV, PL, MS and RKT are inventors of the CDNF-patent, which is owned by Herantis Pharma Plc. MS is a shareholder of Herantis Pharma Plc.

  • The study was supported by grants from the Jane and Aatos Erkko Foundation, Michael J. Fox Foundation for Parkinson’s Research, Eu-ERA-NET, Sigrid Jusélius Foundation, and the Academy of Finland. M.H.V. was supported by grants from the Finnish Cultural Foundation and Finnish Parkinson Foundation.

Funding

  • Jane and Aatos Erkko Foundation

  • Michael J. Fox Foundation

  • EU-Era-Net Neuron

  • Sigrid Juselius Foundation

  • Academy of Finland

  • Finnis Cultural Foundation

  • Finnish Parkinson Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 22, 2017).

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AbstractFullPdf
Mar 201706629
Apr 2017325759
May 2017244256
Jun 2017163439
Jul 201782828
Aug 2017233634
Sep 2017366648
Oct 2017325034
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Total 2017229466381
Jan 201814225
Feb 201810318
Mar 201815376
Apr 2018217434
May 201810469
Jun 2018147852
Jul 20189237
Aug 2018115642
Sep 20180737
Oct 2018917915
Nov 20181219521
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Total 2018133954211
Jan 201981808
Feb 2019121547
Mar 2019312512
Apr 201942810
May 201952120
Jun 201973118
Jul 20195265
Aug 2019103218
Oct 201932212
Nov 201933510
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Total 201965676138
Jan 202073519
Feb 202033223
Mar 20204379
May 202044315
Jun 202037819
Jul 202052119
Aug 20203229
Sep 20201483
Oct 202027810
Nov 202025114
Dec 202046517
Total 202038510157
Jan 202115214
Feb 202115713
Mar 20217656
Apr 202146613
May 20214518
Jun 202115517
Jul 202128419
Aug 202125714
Sep 202116012
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Total 202127761165
Jan 202206911
Feb 20224567
Mar 20221616
Apr 202233811
May 202224512
Jun 20220656
Jul 202232910
Aug 202203415
Sep 202221610
Oct 202223419
Nov 202226514
Dec 202203822
Total 202219550143
Jan 20231388
Total 20231388
Total51239551203
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Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action
Merja H. Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T. Männistö, Raimo K. Tuominen
eNeuro 22 February 2017, 4 (1) ENEURO.0117-16.2017; DOI: 10.1523/ENEURO.0117-16.2017

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Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action
Merja H. Voutilainen, Francesca De Lorenzo, Polina Stepanova, Susanne Bäck, Li-Ying Yu, Päivi Lindholm, Eeva Pörsti, Mart Saarma, Pekka T. Männistö, Raimo K. Tuominen
eNeuro 22 February 2017, 4 (1) ENEURO.0117-16.2017; DOI: 10.1523/ENEURO.0117-16.2017
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Keywords

  • 6-OHDA
  • Additive Effect
  • CDNF
  • ER stress
  • GDNF
  • rat

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