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Research ArticleNew Research, Sensory and Motor Systems

Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits

Katherine J. Zappia, Crystal L. O’Hara, Francie Moehring, Kelvin Y. Kwan and Cheryl L. Stucky
eNeuro 10 February 2017, 4 (1) ENEURO.0069-16.2017; https://doi.org/10.1523/ENEURO.0069-16.2017
Katherine J. Zappia
1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226
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Crystal L. O’Hara
1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226
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Francie Moehring
1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226
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Kelvin Y. Kwan
2Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854
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Cheryl L. Stucky
1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0069-16.2017
PubMed 
28303259
Published By 
Society for Neuroscience
History 
  • Received March 22, 2016
  • Revision received January 26, 2017
  • Accepted January 30, 2017
  • Published online February 10, 2017.
Copyright & Usage 
Copyright © 2017 Zappia et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Katherine J. Zappia1,
  2. Crystal L. O’Hara1,
  3. Francie Moehring1,
  4. Kelvin Y. Kwan2 and
  5. Cheryl L. Stucky1
  1. 1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226
  2. 2Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854
  1. Correspondence should be addressed to either of the following: Cheryl L. Stucky, 8701 Watertown Plank Road, Milwaukee, WI 53226, E-mail: cstucky{at}mcw.edu; or Katherine J. Zappia, 8701 Watertown Plank Road, Milwaukee, WI 53226, E-mail: kzappia{at}mcw.edu.
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Author contributions

  1. Author contributions: K.J.Z. and C.L.S. designed research; K.J.Z., C.L.O., F.M., K.Y.K. performed research; K.J.Z. and C.L.S. analyzed data; K.J.Z. and C.L.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by NIH Grants NS040538 and NS070711 (to C.L.S.) and NS087716 (to K.J.Z.). Funding for K.Y.K. was through the Duncan and Nancy MacMillan Faculty Development Chair Endowment Fund, Busch Biomedical Research Grant, Rutgers Faculty Development Grant, and the NIH Grant R01 DC015000-01. Partial support was provided by the Research and Education Component of the Advancing a Healthier Wisconsin Endowment at the Medical College of Wisconsin. K.J.Z. is a member of the MCW-MSTP, which is partially supported by a T32 grant from NIGMS, GM080202.

Funding

  • NIH - NINDS

    NS040538
  • NIH - NINDS

    NS070711
  • NIH - NINDS

    NS087716
  • NIH - NIGMS

    GM080202
  • Advancing a Healthier Wisconsin Endowment (MCW)

  • NIH - NIDCD

    DC015000
  • Rutgers Faculty Development Grant

  • Duncan and Nancy MacMillan Faculty Development Chair Endowment Fund

  • Busch Biomedical Research Grant

Other Version

  • You are viewing the most recent version of this article.
  • previous version (February 10, 2017).

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Mar 201708150
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Total 202049419176
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Total71665402182
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Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits
Katherine J. Zappia, Crystal L. O’Hara, Francie Moehring, Kelvin Y. Kwan, Cheryl L. Stucky
eNeuro 10 February 2017, 4 (1) ENEURO.0069-16.2017; DOI: 10.1523/ENEURO.0069-16.2017

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Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits
Katherine J. Zappia, Crystal L. O’Hara, Francie Moehring, Kelvin Y. Kwan, Cheryl L. Stucky
eNeuro 10 February 2017, 4 (1) ENEURO.0069-16.2017; DOI: 10.1523/ENEURO.0069-16.2017
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Keywords

  • Advillin
  • cold
  • mechanical
  • sensory neuron
  • somatosensation
  • TRPA1

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