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Research ArticleNew Research, Disorders of the Nervous System

Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine

Jun Zhao and Dan Levy
eNeuro 5 December 2016, 3 (6) ENEURO.0287-16.2016; DOI: https://doi.org/10.1523/ENEURO.0287-16.2016
Jun Zhao
1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, 02215 MA
2Harvard Medical School, Boston, 02115 MA
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Dan Levy
1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, 02215 MA
2Harvard Medical School, Boston, 02115 MA
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0287-16.2016
PubMed 
28127585
Published By 
Society for Neuroscience
History 
  • Received September 20, 2016
  • Revision received November 7, 2016
  • Accepted November 14, 2016
  • Published online December 5, 2016.
Copyright & Usage 
Copyright © 2016 Zhao and Levy This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jun Zhao1,2 and
  2. Dan Levy1,2
  1. 1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, 02215 MA
  2. 2Harvard Medical School, Boston, 02115 MA
  1. Correspondence should be addressed to Dan Levy, PhD, Department of Anesthesia, 330 Brookline Ave., DA717, Boston MA 02215. E-mail: dlevy1{at}bidmc.harvard.edu.
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Author contributions

  1. Author contributions: JZ designed research, performed research, analyzed data. DL designed research, analyzed data, wrote the paper.

Disclosures

  • Authors report no conflict of interest.

  • The study was supported by grants from the NIH/NINDS (NS086830, NS078263 to DL).

Funding

  • NINDS

    NS086830
  • NINDS

    NS078263

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eneuro: 3 (6)
eNeuro
Vol. 3, Issue 6
November/December 2016
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Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine
Jun Zhao, Dan Levy
eNeuro 5 December 2016, 3 (6) ENEURO.0287-16.2016; DOI: 10.1523/ENEURO.0287-16.2016

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Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine
Jun Zhao, Dan Levy
eNeuro 5 December 2016, 3 (6) ENEURO.0287-16.2016; DOI: 10.1523/ENEURO.0287-16.2016
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Keywords

  • afferent
  • cranial meninges
  • headache
  • mechanosensitization
  • migraine
  • trigeminal

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