Article Figures & Data
Figures
- Figure 1.
Experimental timeline used in all experiments. OVX, ovariectomy.
- Figure 2.
Working memory performance of ovariectomized estradiol-treated (E) and cholesterol vehicle-treated (CH) ovariectomized rats in a radial-arm maze during training on short-delay trials in Experiment 1. Delays were imposed between the fourth and fifth arm choices. Mean number of errors of the first eight arm choices (±SEM) at each delay. *p < 0.05 vs. 1-min delay.
- Figure 3.
Effects of estradiol treatment and inhibition of brain estradiol synthesis on a hippocampus-dependent spatial memory task. Rats were ovariectomized and implanted with capsules containing estradiol (E) or cholesterol vehicle (CH). Chronic intracerebroventricular delivery of the aromatase inhibitor letrozole or aCSF vehicle was initiated 1 week before and maintained throughout testing. A, Working memory performance in a radial-arm maze with delays imposed between the fourth and fifth arm choices. Mean number of errors of the first eight arm choices (±SEM) at each delay. B, Mean number of errors of the first eight arm choices (±SEM) averaged across both delays. *p < 0.05 vs. all other groups.
- Figure 4.
Effects of estradiol treatment and antagonism of hippocampal GnRH receptors on a hippocampus-dependent spatial memory task. Rats were ovariectomized and implanted with capsules containing estradiol (E) or cholesterol vehicle (CH). A single bilateral infusion of the long-lasting GnRH receptor antagonist antide or aCSF vehicle was delivered to the hippocampus 1 week before the initiation of testing. A, Working memory performance in a radial-arm maze with delays imposed between the fourth and fifth arm choices. Mean number of errors of the first eight arm choices (±SEM) at each delay. B, Mean number of errors of the first eight arm choices (±SEM) averaged across both delays. *p < 0.05 vs. all other groups.
- Figure 5.
Effects of intrahippocampal delivery of GnRH alone or with an aromatase inhibitor on performance on a hippocampus-dependent spatial memory task. Rats were ovariectomized, and all were implanted with capsules containing cholesterol vehicle. Chronic bilateral intrahippocampal delivery of GnRH, GnRH + the aromatase inhibitor letrozole, or aCSF vehicle was initiated 1 week before and maintained throughout testing. A, Memory performance in a radial-arm maze with delays imposed between the fourth and fifth arm choices. Mean number of errors of the first eight arm choices (±SEM) at each delay. B, Mean number of errors of the first eight arm choices (±SEM) averaged across both delays. *p < 0.05 vs. other groups.
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