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Research ArticleNew Research, Development

Temporary Depletion of Microglia during the Early Postnatal Period Induces Lasting Sex-Dependent and Sex-Independent Effects on Behavior in Rats

Jonathan W. VanRyzin, Stacey J. Yu, Miguel Perez-Pouchoulen and Margaret M. McCarthy
eNeuro 29 November 2016, 3 (6) ENEURO.0297-16.2016; https://doi.org/10.1523/ENEURO.0297-16.2016
Jonathan W. VanRyzin
1Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201
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Stacey J. Yu
2Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201
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Miguel Perez-Pouchoulen
2Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201
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Margaret M. McCarthy
1Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201
2Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0297-16.2016
PubMed 
27957532
Published By 
Society for Neuroscience
History 
  • Received October 4, 2016
  • Revision received November 21, 2016
  • Accepted November 22, 2016
  • Published online November 29, 2016.
Copyright & Usage 
Copyright © 2016 VanRyzin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jonathan W. VanRyzin1,
  2. Stacey J. Yu2,
  3. Miguel Perez-Pouchoulen2 and
  4. Margaret M. McCarthy1,2
  1. 1Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201
  2. 2Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201
  1. Correspondence should be addressed to either of the following: Jonathan W. VanRyzin, 655 W. Baltimore St., BRB-5014, Baltimore, MD 21201. E-mail: jvanryzin{at}umaryland.edu; or Margaret M. McCarthy; E-mail: mmccarthy{at}som.umaryland.edu.
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Author contributions

  1. Author contributions: J.V.R. and M.M.M. designed research; J.V.R. and S.J.Y. performed research; M.P.P. contributed unpublished reagents/analytical tools; J.V.R. analyzed data; J.V.R. and M.M.M. wrote the manuscript.

Disclosures

  • The authors declare no conflicts of interest.

  • This work was funded by NIH Grants R01-MH52716 and R01-DA039062 to M.M.M.

Funding

  • NIH

    R01-MH52716
  • NIH

    R01-DA039062

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Temporary Depletion of Microglia during the Early Postnatal Period Induces Lasting Sex-Dependent and Sex-Independent Effects on Behavior in Rats
Jonathan W. VanRyzin, Stacey J. Yu, Miguel Perez-Pouchoulen, Margaret M. McCarthy
eNeuro 29 November 2016, 3 (6) ENEURO.0297-16.2016; DOI: 10.1523/ENEURO.0297-16.2016

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Temporary Depletion of Microglia during the Early Postnatal Period Induces Lasting Sex-Dependent and Sex-Independent Effects on Behavior in Rats
Jonathan W. VanRyzin, Stacey J. Yu, Miguel Perez-Pouchoulen, Margaret M. McCarthy
eNeuro 29 November 2016, 3 (6) ENEURO.0297-16.2016; DOI: 10.1523/ENEURO.0297-16.2016
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Keywords

  • behavior
  • liposomal clodronate
  • microglia
  • postnatal development

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