Skip to main content

Umbrella menu

  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SfN.org
  • eNeuro
  • The Journal of Neuroscience
  • Neuronline
  • BrainFacts.org

User menu

  • My alerts

Search

  • Advanced search
eNeuro
  • My alerts
eNeuro

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Latest Articles
    • Issue Archive
    • Editorials
    • Research Highlights
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • EDITORIAL BOARD
  • BLOG
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
PreviousNext
Review, Disorders of the Nervous System

Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids

Harel Adrian, Kvist Mårten, Nuutinen Salla and Välimaa Lasse
eNeuro 8 December 2016, 3 (6) ENEURO.0294-16.2016; DOI: https://doi.org/10.1523/ENEURO.0294-16.2016
Harel Adrian
Medicortex Finland Oy, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kvist Mårten
Medicortex Finland Oy, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nuutinen Salla
Medicortex Finland Oy, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nuutinen Salla
Välimaa Lasse
Medicortex Finland Oy, Itäinen Pitkäkatu 4 B, 20520 Turku, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Välimaa Lasse
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Traumatic brain injuries (TBIs) are caused by a hit to the head or a sudden acceleration/deceleration movement of the head. Mild TBIs (mTBIs) and concussions are difficult to diagnose. Imaging techniques often fail to find alterations in the brain, and computed tomography exposes the patient to radiation. Brain-specific biomolecules that are released upon cellular damage serve as another means of diagnosing TBI and assessing the severity of injury. These biomarkers can be detected from samples of body fluids using laboratory tests. Dozens of TBI biomarkers have been studied, and research related to them is increasing. We reviewed the recent literature and selected 12 biomarkers relevant to rapid and accurate diagnostics of TBI for further evaluation. The objective was especially to get a view of the temporal profiles of the biomarkers’ rise and decline after a TBI event. Most biomarkers are rapidly elevated after injury, and they serve as diagnostics tools for some days. Some biomarkers are elevated for months after injury, although the literature on long-term biomarkers is scarce. Clinical utilization of TBI biomarkers is still at a very early phase despite years of active research.

  • biomarker
  • diagnostics
  • TBI
  • traumatic brain injury

Footnotes

  • Authors report no conflict of interest.

  • Manuscript has been written at company’s own cost.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

View Full Text
Back to top

In this issue

eneuro: 3 (6)
eNeuro
Vol. 3, Issue 6
November/December 2016
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
Print
View Full Page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
Harel Adrian, Kvist Mårten, Nuutinen Salla, Välimaa Lasse
eNeuro 8 December 2016, 3 (6) ENEURO.0294-16.2016; DOI: 10.1523/ENEURO.0294-16.2016

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids
Harel Adrian, Kvist Mårten, Nuutinen Salla, Välimaa Lasse
eNeuro 8 December 2016, 3 (6) ENEURO.0294-16.2016; DOI: 10.1523/ENEURO.0294-16.2016
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Significance Statement
    • Introduction
    • Biomarkers
    • Discussion
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • biomarker
  • diagnostics
  • tbi
  • traumatic brain injury

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Review

  • A Roadmap for Understanding Memory: Decomposing Cognitive Processes into Operations and Representations
  • Synaptic Wiring of Corticostriatal Circuits in Basal Ganglia: Insights into the Pathogenesis of Neuropsychiatric Disorders
  • Echoes of Emotions Past: How Neuromodulators Determine What We Recollect
Show more Review

Disorders of the Nervous System

  • Mega-Analysis of Gene Expression in Mouse Models of Alzheimer’s Disease
  • Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light
  • MicroRNA-137 Drives Epigenetic Reprogramming in the Adult Amygdala and Behavioral Changes after Adolescent Alcohol Exposure
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Reviews
  • Home
  • Blog
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Articles

  • Early Release
  • Latest Articles
  • Issue Archive
  • Video Archive
  • Editorials

For Authors

  • Information for Authors
  • Contact Information

About

  • Overview
  • Editorial Board
  • Advertise
  • For the Media
  • Privacy Policy
  • Contact Us
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2019 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.