Research ArticleNegative Results, Disorders of the Nervous System

Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury

Xingxing Wang, Yuichi Sekine, Alexandra B. Byrne, William B.J. Cafferty, Marc Hammarlund and Stephen M. Strittmatter
eNeuro 12 December 2016, 3 (6) ENEURO.0270-16.2016; https://doi.org/10.1523/ENEURO.0270-16.2016

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0270-16.2016
PubMed 
28032120
Published By 
Society for Neuroscience
History 
  • Received September 6, 2016
  • Revision received November 16, 2016
  • Accepted December 7, 2016
  • Published online December 12, 2016.
Copyright & Usage 
Copyright © 2016 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Xingxing Wang1,2,3,*,
  2. Yuichi Sekine1,2,3,*,
  3. Alexandra B. Byrne1,2,4,
  4. William B.J. Cafferty3,
  5. Marc Hammarlund1,2,4 and
  6. Stephen M. Strittmatter1,2,3
  1. 1Program in Cellular Neuroscience, Neurodegeneration & Repair, Yale University School of Medicine, New Haven, CT 06536
  2. 2Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520
  3. 3Department of Neurology, Yale University School of Medicine, New Haven, CT 06520
  4. 4Department of Genetics, Yale University School of Medicine, New Haven CT 06520
  1. Correspondence should be addressed to Stephen M. Strittmatter, CNNR Program, BCMM 436, Yale University School of Medicine, 295 Congress Ave., New Haven, CT 06536. E-mail: stephen.strittmatter{at}yale.edu.
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Author contributions

  1. Author Contributions: X.W. and Y.S. performed experiments and collected data. A.B., W.C., M.H., and S.M.S. designed experiments. X.W., Y.S., and S.M.S. analyzed data and wrote the paper.

  2. ↵* X.W. and Y.S. contributed equally to this work.

Disclosures

  • Conflicts of Interest: S.M.S. is a co-founder of Axerion Therapeutics seeking to develop NgR1-based therapeutics.

  • This work was supported by grants from NIH and Falk Medical Research Trust to S.M.S.

Funding

  • NINDS

    R01NS080388

  • Falk Medical Research Trust

  • NINDS

    R01NS098817

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Online Impact

 

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Article usage: December 2016 to November 2025

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Total 202562602169
Total57368451523
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eneuro: 3 (6)
eNeuro
Vol. 3, Issue 6
November/December 2016
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Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury
Xingxing Wang, Yuichi Sekine, Alexandra B. Byrne, William B.J. Cafferty, Marc Hammarlund, Stephen M. Strittmatter
eNeuro 12 December 2016, 3 (6) ENEURO.0270-16.2016; DOI: 10.1523/ENEURO.0270-16.2016
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