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Research ArticleNew Research, Development

Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity

Milo R. Smith, Poromendro Burman, Masato Sadahiro, Brian A. Kidd, Joel T. Dudley and Hirofumi Morishita
eNeuro 15 December 2016, 3 (6) ENEURO.0240-16.2016; DOI: https://doi.org/10.1523/ENEURO.0240-16.2016
Milo R. Smith
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029
4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
6Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
7Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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Poromendro Burman
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029
3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029
4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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Masato Sadahiro
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029
3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029
4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
6Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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  • ORCID record for Masato Sadahiro
Brian A. Kidd
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
7Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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Joel T. Dudley
2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
7Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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Hirofumi Morishita
1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029
3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029
4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0240-16.2016
PubMed 
28101530
Published By 
Society for Neuroscience
History 
  • Received August 9, 2016
  • Revision received November 1, 2016
  • Accepted November 12, 2016
  • Published online December 15, 2016.
Copyright & Usage 
Copyright © 2016 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Milo R. Smith1,2,3,4,5,6,7,8,
  2. Poromendro Burman1,3,4,5,8,
  3. Masato Sadahiro1,3,4,5,6,8,
  4. Brian A. Kidd2,7,
  5. Joel T. Dudley2,7 and
  6. Hirofumi Morishita1,3,4,5,8
  1. 1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  2. 2Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  3. 3Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  4. 4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  5. 5Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  6. 6Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  7. 7Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  8. 8Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029
  1. Address correspondence to either Joel T. Dudley or Hirofumi Morishita, 1 Gustave L Levy Place, New York, NY 10029, E-mail: joel.dudley{at}mssm.edu or hirofumi.morishita{at}mssm.edu.
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Author contributions

  1. Author contributions: M.R.S., B.A.K., J.T.D., and H.M. designed research; M.R.S., P.B., M.S., and H.M. performed research; M.R.S., B.A.K., and H.M. analyzed data; and M.R.S., B.A.K., J.T.D., and H.M. wrote the paper.

View Abstract

Disclosures

  • Authors declare no competing financial interests.

  • This research was funded by a Traineeship, National Institute of Child Health and Human Development-Interdisciplinary Training in Systems and Developmental Biology and Birth Defects Grant T32H-D0-75735 (to M.R.S.); the Mindich Child Health and Development Institute Pilot Fund (to J.T.D. and H.M.); National Institute of Environmental Health Sciences Grant P30-ES-023515 (to J.T.D. and H.M.), the Knights Templar Eye Foundation (to H.M.); the March of Dimes (to H.M.); the Whitehall Foundation (to H.M.); and National Institutes of Health Grants R01-DK-098242 and U54-CA-189201 (to J.T.D.), R01-EY-024918, R01-EY-026053, and R21 MH106919 (to H.M.).

Funding

  • NEI

    EY024918; EY026053
  • Knights Templar Eye Foundation (KTEF)

    100001209
  • march of dimes

  • HHS | NIH | National Institute of Child Health and Human Development (NICHD)

    100000071; HD075735
  • NIEHS

    ES023515
  • mindich child heath and development institute

  • Whitehall Foundation (Whitehall Foundation, Inc.)

    100001391
  • NIH

    DK098242; CA189201

Other Version

  • previous version (December 15, 2016).
  • You are viewing the most recent version of this article.

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Dec 2016175034
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Mar 20174626361
Apr 2017636935
May 2017427638
Jun 2017544128
Jul 2017202830
Aug 2017252525
Sep 2017345037
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Total 201995775186
Jan 202052712
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Mar 202013110
Apr 202022312
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Jun 202012119
Jul 202023313
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Total 202057407200
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Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity
Milo R. Smith, Poromendro Burman, Masato Sadahiro, Brian A. Kidd, Joel T. Dudley, Hirofumi Morishita
eNeuro 15 December 2016, 3 (6) ENEURO.0240-16.2016; DOI: 10.1523/ENEURO.0240-16.2016

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Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity
Milo R. Smith, Poromendro Burman, Masato Sadahiro, Brian A. Kidd, Joel T. Dudley, Hirofumi Morishita
eNeuro 15 December 2016, 3 (6) ENEURO.0240-16.2016; DOI: 10.1523/ENEURO.0240-16.2016
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Keywords

  • bioinformatics
  • critical period
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