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Research ArticleNew Research, Neuronal Excitability

Regulation of Physical Microglia–Neuron Interactions by Fractalkine Signaling after Status Epilepticus

Ukpong B. Eyo, Jiyun Peng, Madhuvika Murugan, Mingshu Mo, Almin Lalani, Ping Xie, Pingyi Xu, David J. Margolis and Long-Jun Wu
eNeuro 29 December 2016, 3 (6) ENEURO.0209-16.2016; https://doi.org/10.1523/ENEURO.0209-16.2016
Ukpong B. Eyo
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
2Department of Neurology, Mayo Clinic, Rochester, MN 55905
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  • ORCID record for Ukpong B. Eyo
Jiyun Peng
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
2Department of Neurology, Mayo Clinic, Rochester, MN 55905
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Madhuvika Murugan
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
2Department of Neurology, Mayo Clinic, Rochester, MN 55905
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Mingshu Mo
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
3Department of Neurology, First Affiliated Hospital of Guangzhou Medical University Guangdong, 510120, China
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Almin Lalani
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
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Ping Xie
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
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Pingyi Xu
3Department of Neurology, First Affiliated Hospital of Guangzhou Medical University Guangdong, 510120, China
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David J. Margolis
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
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Long-Jun Wu
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
2Department of Neurology, Mayo Clinic, Rochester, MN 55905
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0209-16.2016
PubMed 
28101527
Published By 
Society for Neuroscience
History 
  • Received July 17, 2016
  • Revision received November 22, 2016
  • Accepted December 20, 2016
  • Published online December 29, 2016.
Copyright & Usage 
Copyright © 2016 Eyo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ukpong B. Eyo1,2,
  2. Jiyun Peng1,2,
  3. Madhuvika Murugan1,2,
  4. Mingshu Mo1,3,
  5. Almin Lalani1,
  6. Ping Xie1,
  7. Pingyi Xu3,
  8. David J. Margolis1 and
  9. Long-Jun Wu1,2
  1. 1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
  2. 2Department of Neurology, Mayo Clinic, Rochester, MN 55905
  3. 3Department of Neurology, First Affiliated Hospital of Guangzhou Medical University Guangdong, 510120, China
  1. Correspondence should be addressed to Dr. Long-Jun Wu, B333 Nelson Labs, 604 Allison Road, Piscataway, NJ, 08854-6990. E‐mail: lwu{at}dls.rutgers.edu.
View Full Text

Author contributions

  1. Author Contributions: UBE and LJW designed the research; UBE, JP, MM, AL, and MM performed the research; PX and DJM contributed analytic tools, UBE and MM analyzed the data; UBE and LJW wrote the paper.

Disclosures

  • Authors report no conflict of interest.

  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) [R01NS088627] [100000065]; HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) [100000066].

Funding

  • NIH | National Institute of Neurological Disorders and Stroke

    R01NS088627
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; R21DE025689
  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    100000066; T32ES007148
  • HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)

    100000065; R01NS094450

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  • You are viewing the most recent version of this article.
  • previous version (December 29, 2016).

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Regulation of Physical Microglia–Neuron Interactions by Fractalkine Signaling after Status Epilepticus
Ukpong B. Eyo, Jiyun Peng, Madhuvika Murugan, Mingshu Mo, Almin Lalani, Ping Xie, Pingyi Xu, David J. Margolis, Long-Jun Wu
eNeuro 29 December 2016, 3 (6) ENEURO.0209-16.2016; DOI: 10.1523/ENEURO.0209-16.2016

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Regulation of Physical Microglia–Neuron Interactions by Fractalkine Signaling after Status Epilepticus
Ukpong B. Eyo, Jiyun Peng, Madhuvika Murugan, Mingshu Mo, Almin Lalani, Ping Xie, Pingyi Xu, David J. Margolis, Long-Jun Wu
eNeuro 29 December 2016, 3 (6) ENEURO.0209-16.2016; DOI: 10.1523/ENEURO.0209-16.2016
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Keywords

  • epilepsy
  • Fractalkine
  • glutamate
  • interleukin-1β
  • microglia
  • seizure

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