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Research ArticleNegative Results, Disorders of the Nervous System

Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice

Joram D. Mul, Jia Zheng and Laurie J. Goodyear
eNeuro 12 December 2016, 3 (6) ENEURO.0201-16.2016; https://doi.org/10.1523/ENEURO.0201-16.2016
Joram D. Mul
1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215
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Jia Zheng
1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215
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Laurie J. Goodyear
1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215
2Department of Medicine, Brigham, and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02215
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0201-16.2016
PubMed 
28058270
Published By 
Society for Neuroscience
History 
  • Received July 12, 2016
  • Revision received October 6, 2016
  • Accepted October 28, 2016
  • Published online December 12, 2016.
Copyright & Usage 
Copyright © 2016 Mul et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Joram D. Mul1,
  2. Jia Zheng1 and
  3. Laurie J. Goodyear1,2
  1. 1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215
  2. 2Department of Medicine, Brigham, and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02215
  1. Correspondence should be addressed to Joram D. Mul, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 AD, Amsterdam, The Netherlands. E-mail: joramdmul{at}gmail.com.
  • J.D. Mul’s present address: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 AD, Amsterdam, The Netherlands, and Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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Author contributions

  1. Author contributions: J.D.M. and L.J.G. designed research; J.D.M. and J.Z. performed research; J.D.M. analyzed data; J.D.M., J.Z., and L.J.G. wrote the paper.

  • J.D. Mul’s present address: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Postbus 22660, 1100 AD, Amsterdam, The Netherlands, and Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.

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Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Department of Health and Human Services/National Institutes of Health/National Institute for Health Research Grants R01-DK-099511 and R01-DK-101043 (to L.J.G.) and 5P30-DK-36836 (to Diabetes and Endocrinology Research Center, Joslin Diabetes Center). J.D.M. was supported by a mentor-based fellowship (7-08-MN-21) awarded to L.J.G. from the American Diabetes Association.

Funding

  • DH | National Institute for Health Research (NIHR)

    501100000272; R01-DK-099511
  • DH | National Institute for Health Research (NIHR)

    501100000272; R01-DK-101043
  • DH | National Institute for Health Research (NIHR)

    501100000272; 5P30-DK-36836
  • American Diabetes Association

    7-08-MN-21

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eneuro: 3 (6)
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November/December 2016
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Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice
Joram D. Mul, Jia Zheng, Laurie J. Goodyear
eNeuro 12 December 2016, 3 (6) ENEURO.0201-16.2016; DOI: 10.1523/ENEURO.0201-16.2016

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Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice
Joram D. Mul, Jia Zheng, Laurie J. Goodyear
eNeuro 12 December 2016, 3 (6) ENEURO.0201-16.2016; DOI: 10.1523/ENEURO.0201-16.2016
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Keywords

  • anhedonia
  • animal model
  • depression
  • forced swimming
  • stress
  • voluntary wheel running

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