Research ArticleNew Research, Neuronal Excitability

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP

Christopher M. Bartley, Rachel A. O’Keefe, Anna Blice-Baum, Mihaela-Rita Mihailescu, Xuan Gong, Laura Miyares, Esra Karaca and Angélique Bordey
eNeuro 1 November 2016, 3 (6) ENEURO.0092-16.2016; https://doi.org/10.1523/ENEURO.0092-16.2016

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0092-16.2016
PubMed 
27957526
Published By 
Society for Neuroscience
History 
  • Received April 25, 2016
  • Revision received October 25, 2016
  • Accepted October 27, 2016
  • Published online November 1, 2016.
Copyright & Usage 
Copyright © 2016 Bartley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Christopher M. Bartley1,2,
  2. Rachel A. O’Keefe1,
  3. Anna Blice-Baum3,
  4. Mihaela-Rita Mihailescu3,
  5. Xuan Gong1,4,
  6. Laura Miyares1,
  7. Esra Karaca1 and
  8. Angélique Bordey1
  1. 1Departments of Neurosurgery, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510
  2. 2Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510
  3. 3Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282
  4. 4Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China
  1. Correspondence should be addressed to Angélique Bordey, Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St., FMB 422, New Haven, CT 06520-8082. E-mail: angelique.bordey{at}yale.edu.

  • Christopher M. Bartley’s present address: UCSF Department of Psychiatry, 401 Parnassus Ave., Box 0984, San Francisco, CA 94143-0984.

  • Anna Blice-Baum’s present address: Department of Biological Sciences, Sam Houston State University, 1900 Ave. I, Lee Drain Building Suite 300, P.O. Box 2116, Huntsville, TX 77340.

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Author contributions

  1. Author contributions: C.M.B. and R.A.O. performed most of the experiments; A.B.-B. and M.-R.M. provided human recombinant FMRP; X.G. and E.K. performed some of the coimmunoprecipitation experiments; A.B. and C.M.B. designed the experiments and wrote the manuscript.

  • Christopher M. Bartley’s present address: UCSF Department of Psychiatry, 401 Parnassus Ave., Box 0984, San Francisco, CA 94143-0984.

  • Anna Blice-Baum’s present address: Department of Biological Sciences, Sam Houston State University, 1900 Ave. I, Lee Drain Building Suite 300, P.O. Box 2116, Huntsville, TX 77340.

Disclosures

  • The authors declare no competing financial interests.

  • McKnight Endowment Fund for Neuroscience award (A.B.), NIH grant R15HD078017 (M.R.M).

Funding

  • HHS | NIH | National Institute of Child Health and Human Development (NICHD)

    100000071; R15HD078017

  • McKnight Endowment Fund for Neuroscience

    100000872

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Total64459461712
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eneuro: 3 (6)
eNeuro
Vol. 3, Issue 6
November/December 2016
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Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP
Christopher M. Bartley, Rachel A. O’Keefe, Anna Blice-Baum, Mihaela-Rita Mihailescu, Xuan Gong, Laura Miyares, Esra Karaca, Angélique Bordey
eNeuro 1 November 2016, 3 (6) ENEURO.0092-16.2016; DOI: 10.1523/ENEURO.0092-16.2016
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