Research ArticleNew Research, Disorders of the Nervous System

Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame and Mara Dierssen
eNeuro 19 October 2016, 3 (5) ENEURO.0103-16.2016; https://doi.org/10.1523/ENEURO.0103-16.2016

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0103-16.2016
PubMed 
27844057
Published By 
Society for Neuroscience
History 
  • Received May 2, 2016
  • Revision received August 26, 2016
  • Accepted September 8, 2016
  • Published online October 19, 2016.
Copyright & Usage 
Copyright © 2016 Catuara-Solarz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Silvina Catuara-Solarz1,2,3,
  2. Jose Espinosa-Carrasco1,2,4,
  3. Ionas Erb2,4,
  4. Klaus Langohr3,5,
  5. Juan Ramon Gonzalez6,7,
  6. Cedric Notredame2,4 and
  7. Mara Dierssen1,3,8
  1. 1Cellular and Systems Neurobiology, Systems Biology Program, the Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), 08003, Barcelona, Spain
  2. 2Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
  3. 3Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, 08003, Spain
  4. 4Comparative Bioinformatics, Bioinformatics, and Genomics Program, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Barcelona, 08003, Spain
  5. 5Department of Statistics and Operations Research, Universitat Politècnica De Catalunya/BarcelonaTech, Barcelona, 08034, Spain
  6. 6Centre for Research in Environmental Epidemiology, Barcelona, 08003, Spain
  7. 7Centro De Investigación Biomédica En Red De Epidemiología Y Salud Pública, Madrid, 28029, Spain
  8. 8Centro De Investigación Biomédica En Red De Enfermedades Raras, Madrid, 28029, Spain
  1. Correspondence should be addressed to M. Dierssen, Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain. E-mail: mara.dierssen{at}crg.eu.
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Author contributions

Disclosures

  • Authors report no conflict of interest.

  • Authors Contribution: S.C.S. designed research, performed research, analyzed data, wrote the paper; J.E.-C., I.E., K.L., J.R.G. analyzed data; C.N. supervised the PCA analysis; M.D. provided financial support, designed research, wrote the paper.

  • This research was supported by DIUE of Generalitat de Catalunya (Grups consolidats SGR 2014/1125); Fondation Jérôme Lejeune (Paris, France); Spanish Ministry of Economy and Finance (MINECO) grants SAF2013-49129-C2-1-R, BFU2011-28575, and MTM2015-64465-C2-1-R CDTI (“Smartfoods”); the CIBER of Rare Diseases (ISCIII initiative); and EU-Era Net Neuron PCIN-2013-060. The CRG has received support as a Severo Ochoa Center of Excellence SEV- 2012-O208. S.C.-S. received a FPI doctoral Fellowship from the MINECO (SAF2010-16427).

Funding

  • MINECO | Consejo Superior de Investigaciones Científicas (CSIC)

    501100003339; SAF2013-49129-C2-1-R

  • DIUE of Generalitat de Catalunya (Grups consolidats)

    SGR 2014/1125

  • Fondation Jérôme Lejeune

    N.A

  • CDTI Smartfoods, CIBER of Rare Disease ISCIII initiave

    N.A.

  • EU-Era Net Neuron

    PCIN-2013- 060

  • Severo Ochoa Center of Excellence

    SEV- 2012-0208

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Article usage: November 2016 to October 2024

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Total 202286512127
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Aug 202485418
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Total 202454693120
Total66354961209
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eneuro: 3 (5)
eNeuro
Vol. 3, Issue 5
September/October 2016
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Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
eNeuro 19 October 2016, 3 (5) ENEURO.0103-16.2016; DOI: 10.1523/ENEURO.0103-16.2016
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