Research ArticleNew Research, Cognition and Behavior

Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption

Nadine Schweizer, Thomas Viereckel, Casey J.A. Smith-Anttila, Karin Nordenankar, Emma Arvidsson, Souha Mahmoudi, André Zampera, Hanna Wärner Jonsson, Jonas Bergquist, Daniel Lévesque, Åsa Konradsson-Geuken, Malin Andersson, Sylvie Dumas and Åsa Wallén-Mackenzie
eNeuro 15 September 2016, 3 (5) ENEURO.0264-16.2016; https://doi.org/10.1523/ENEURO.0264-16.2016

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0264-16.2016
PubMed 
27699212
Published By 
Society for Neuroscience
History 
  • Received September 2, 2016
  • Accepted September 8, 2016
  • Published online September 15, 2016.
Copyright & Usage 
Copyright © 2016 Schweizer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Nadine Schweizer1,*,
  2. Thomas Viereckel1,2,*,
  3. Casey J.A. Smith-Anttila2,
  4. Karin Nordenankar2,
  5. Emma Arvidsson1,
  6. Souha Mahmoudi3,
  7. André Zampera4,
  8. Hanna Wärner Jonsson5,
  9. Jonas Bergquist6,
  10. Daniel Lévesque3,
  11. Åsa Konradsson-Geuken1,
  12. Malin Andersson5,
  13. Sylvie Dumas4 and
  14. Åsa Wallén-Mackenzie1
  1. 1Department of Organismal Biology, Uppsala University, SE-752 36 Uppsala, Sweden
  2. 2Department of Neuroscience, Uppsala University, SE-751 24 Uppsala, Sweden
  3. 3Faculty of Pharmacy, Université de Montréal, Montréal, QC H3T 1J4, Canada
  4. 4Oramacell, 75006 Paris, France
  5. 5Department of Pharmaceutical Biosciences, Uppsala University, SE-751 24 Uppsala, Sweden
  6. 6Department of Chemistry, BMC - Analytical Chemistry and Neurochemistry, Uppsala University, SE-751 24 Uppsala, Sweden
  1. Correspondence should be addressed to Åsa Wallén-Mackenzie, Uppsala University, Department of Organismal Biology/Comparative Physiology, Norbyvägen 18A, SE-752 36 Uppsala, Sweden. E-mail: asa.mackenzie{at}ebc.uu.se.

  • C.J.A. Smith-Anttila’s present address: Department of Anatomy and Neurosciences, The University of Melbourne, Victoria 3010, Australia; E. Arvidsson’s present address: Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden; N. Schweizer’s and K. Nordenankar’s present address: Department of Pharmaceutical Biosciences, Uppsala University, SE-751 24 Uppsala, Sweden.

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Author contributions

  1. Author contributions: N.S., T.V., C.J.A.S.-A., D.L., Å.K.-G., M.A., S.D., and Å.W.-M. designed research; N.S., T.V., C.J.A.S.-A., K.N., E.A., S.M., A.Z., H.W.J., J.B., D.L., M.A., S.D., and Å.W.-M. performed research; N.S., T.V., C.J.A.S.-A., A.Z., J.B., D.L., Å.K.-G., M.A., S.D., and Å.W.-M. analyzed data; N.S., T.V., C.J.A.S.-A., Å.K.-G., and Å.W.-M. wrote the paper.

  2. ↵* N.S. and T.V. contributed equally to this work.

  • C.J.A. Smith-Anttila’s present address: Department of Anatomy and Neurosciences, The University of Melbourne, Victoria 3010, Australia; E. Arvidsson’s present address: Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden; N. Schweizer’s and K. Nordenankar’s present address: Department of Pharmaceutical Biosciences, Uppsala University, SE-751 24 Uppsala, Sweden.

Disclosures

  • The authors declare no competing interests.

  • This work was supported by grants from the Swedish Research Council (Vetenskapsrådet 2013-4657, 2014-3804, 2011-4423, 2015-4870, and 2012-2304), Uppsala University, The Swedish Brain Foundation, Parkinsonfonden, Hållsten Research Foundation, and the research foundations of Gösta Lind, Åhlén, and Åke Wiberg.

  • Sylvie Dumas is the owner of Oramacell, Paris, France.

Funding

  • Swedish research council

    2013-4657; 2014-3804; 2011-4423; 2015-4870; 2012-2304

  • The brain foundation

  • Bertil Hållsten Research Foundation

  • Foundation of Gösta Lind

  • Foundation of Åhlén

  • Foundation of Åke Wiberg

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Total 202548427133
Total65974101783
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eneuro: 3 (5)
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September/October 2016
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Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption
Nadine Schweizer, Thomas Viereckel, Casey J.A. Smith-Anttila, Karin Nordenankar, Emma Arvidsson, Souha Mahmoudi, André Zampera, Hanna Wärner Jonsson, Jonas Bergquist, Daniel Lévesque, Åsa Konradsson-Geuken, Malin Andersson, Sylvie Dumas, Åsa Wallén-Mackenzie
eNeuro 15 September 2016, 3 (5) ENEURO.0264-16.2016; DOI: 10.1523/ENEURO.0264-16.2016
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