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Research ArticleNew Research, Disorders of the Nervous System

Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice

Jay M. Truitt, Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W. Lasek, R. Adron Harris and R. Dayne Mayfield
eNeuro 19 October 2016, 3 (5) ENEURO.0256-16.2016; https://doi.org/10.1523/ENEURO.0256-16.2016
Jay M. Truitt
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Yuri A. Blednov
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Jillian M. Benavidez
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Mendy Black
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Olga Ponomareva
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Jade Law
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Morgan Merriman
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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  • ORCID record for Morgan Merriman
Sami Horani
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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  • ORCID record for Sami Horani
Kelly Jameson
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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Amy W. Lasek
2Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612
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R. Adron Harris
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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R. Dayne Mayfield
1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
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  • ORCID record for R. Dayne Mayfield
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0256-16.2016
PubMed 
27822501
Published By 
Society for Neuroscience
History 
  • Received September 12, 2016
  • Accepted September 12, 2016
  • Published online October 19, 2016.
Copyright & Usage 
Copyright © 2016 Truitt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Jay M. Truitt1,
  2. Yuri A. Blednov1,
  3. Jillian M. Benavidez1,
  4. Mendy Black1,
  5. Olga Ponomareva1,
  6. Jade Law1,
  7. Morgan Merriman1,
  8. Sami Horani1,
  9. Kelly Jameson1,
  10. Amy W. Lasek2,
  11. R. Adron Harris1 and
  12. R. Dayne Mayfield1
  1. 1Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas 78712
  2. 2Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612
  1. Correspondence should be addressed to Dr. R. Dayne Mayfield, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, MBB 1.124, Austin, TX 78712. E-mail: dayne.mayfield{at}austin.utexas.edu.
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Author contributions

  1. Author contributions: Y.A.B., R.A.H., and R.D.M. designed research; J.M.T., J.M.B., M.B., O.P., J.L., M.M., S.H., and K.J. performed research; A.W.L. contributed unpublished reagents/analytical tools; J.M.T., Y.A.B., O.P., M.M., S.H., K.J., and R.D.M. analyzed data; J.M.T. and R.D.M. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism Grants AA-012404, AA-013520, AA-012404, and AA-0209260.

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  • You are viewing the most recent version of this article.
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Nov 201606733
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Total 2016010754
Jan 201702712
Feb 201703013
Mar 201703710
Apr 2017132221
May 2017112022
Jun 201741926
Jul 201741921
Aug 2017174743
Sep 2017143224
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Total 2017125409262
Jan 201814327
Feb 20188314
Mar 201810273
Apr 2018114317
May 20187509
Jun 2018184020
Jul 20185388
Aug 201893312
Sep 201836810
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Total 201894935111
Jan 201981363
Feb 201991216
Mar 201966810
Apr 20197318
May 20192194
Jun 201952712
Jul 201923415
Aug 2019112617
Oct 20191206
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Dec 20191176
Total 20196052496
Jan 20205267
Feb 202001715
Mar 20203186
May 20202105
Jun 202011612
Jul 20200228
Aug 20201128
Sep 20203315
Oct 202005519
Nov 20205417
Dec 20208589
Total 202028306101
Jan 20214459
Feb 202123712
Mar 202175113
Apr 20214477
May 202115519
Jun 20210437
Jul 202114717
Aug 202115020
Sep 202114010
Oct 202125428
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Total 202127566174
Jan 202235013
Feb 202221621
Mar 202224414
Apr 20222375
May 202214415
Jun 202225417
Jul 202202910
Aug 202213514
Sep 202242514
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Total 202224421160
Jan 202313810
Feb 20230329
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Apr 20230385
May 202314022
Jun 20230423
Jul 202324625
Aug 202314030
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Total 202315506173
Jan 20241459
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Mar 202425517
Apr 202465222
May 202455022
Jun 202436710
Jul 202426021
Aug 202494513
Sep 202434513
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Total 202458602175
Jan 202545317
Feb 20251608
Mar 202534816
Apr 202534219
May 20252436
Jun 202556716
Jul 2025116633
Aug 202556028
Sep 2025510120
Oct 202566211
Nov 202596726
Dec 2025119338
Total 202565762238
Jan 2026149019
Feb 20261315519
Mar 202657559
Apr 202653421
Total 202637354118
Total53354921662
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Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice
Jay M. Truitt, Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W. Lasek, R. Adron Harris, R. Dayne Mayfield
eNeuro 19 October 2016, 3 (5) ENEURO.0256-16.2016; DOI: 10.1523/ENEURO.0256-16.2016

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Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice
Jay M. Truitt, Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W. Lasek, R. Adron Harris, R. Dayne Mayfield
eNeuro 19 October 2016, 3 (5) ENEURO.0256-16.2016; DOI: 10.1523/ENEURO.0256-16.2016
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Keywords

  • alcohol
  • astrocytes
  • microglia
  • neurons
  • sulfasalazine
  • TPCA-1
  • Cre recombinase
  • nucleus accumbens
  • central amygdala
  • DID
  • binge drinking

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