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Research ArticleNew Research, Disorders of the Nervous System

Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice

Terry C. Yin, Jaymie R. Voorhees, Rachel M. Genova, Kevin C. Davis, Ashley M. Madison, Jeremiah K. Britt, Coral J. Cintrón-Pérez, Latisha McDaniel, Matthew M. Harper and Andrew A. Pieper
eNeuro 11 October 2016, 3 (5) ENEURO.0220-16.2016; DOI: https://doi.org/10.1523/ENEURO.0220-16.2016
Terry C. Yin
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Jaymie R. Voorhees
2Department of Psychiatry, Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Rachel M. Genova
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Kevin C. Davis
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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  • ORCID record for Kevin C. Davis
Ashley M. Madison
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Jeremiah K. Britt
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Coral J. Cintrón-Pérez
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Latisha McDaniel
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Matthew M. Harper
3Department of Veteran Affairs Center for the Prevention and Treatment of Visual Loss, University of Iowa Carver College of Medicine, Iowa City, IA 52242
4Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242
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Andrew A. Pieper
1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
5Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
6Department of Free Radical and Radiation Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
7Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, IA 52242
8Weill Cornell Autism Research Program, Weill Cornell Medicine, Cornell University, New York, NY 10065
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0220-16.2016
PubMed 
27822499
Published By 
Society for Neuroscience
History 
  • Received July 29, 2016
  • Revision received September 9, 2016
  • Accepted October 6, 2016
  • Published online October 11, 2016.
Copyright & Usage 
Copyright © 2016 Yin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Terry C. Yin1,
  2. Jaymie R. Voorhees2,
  3. Rachel M. Genova1,
  4. Kevin C. Davis1,
  5. Ashley M. Madison1,
  6. Jeremiah K. Britt1,
  7. Coral J. Cintrón-Pérez1,
  8. Latisha McDaniel1,
  9. Matthew M. Harper3,4 and
  10. Andrew A. Pieper1,5,6,7,8
  1. 1Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  2. 2Department of Psychiatry, Interdisciplinary Graduate Program in Human Toxicology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  3. 3Department of Veteran Affairs Center for the Prevention and Treatment of Visual Loss, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  4. 4Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  5. 5Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  6. 6Department of Free Radical and Radiation Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  7. 7Department of Veteran Affairs, University of Iowa Carver College of Medicine, Iowa City, IA 52242
  8. 8Weill Cornell Autism Research Program, Weill Cornell Medicine, Cornell University, New York, NY 10065
  1. Correspondence should be addressed to Andrew A. Pieper, Neurology and Free Radical & Radiation Biology, Department of Veterans Affairs, University of Iowa Carver College of Medicine, 415 Newton Road, Iowa City, IA 52242. E-mail: andrew-pieper{at}uiowa.edu.
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Author contributions

  1. Author contributions: T.C.Y., J.R.V., R.M.G., C.J.C.-P., L.M., M.M.H., and A.A.P. designed research; T.C.Y., J.R.V., R.M.G., K.D., A.M., J.K.B., and A.A.P. performed research; T.C.Y., J.R.V., R.M.G., K.D., A.M., J.K.B., C.J.C.-P., L.M., M.M.H., and A.A.P. analyzed data; T.C.Y., M.M.H., and A.A.P. wrote the paper.

Disclosures

  • Authors report no conflict of interest.

  • This work was supported by funds from Calico LLC (California Life Company) and from an anonymous donor to the Mary Alice Smith Fund for Neuropsychiatry Research to A.A.P.

Funding

  • Calico LLC

  • Mary Alice Smith Fund for Neuropsychiatry Research

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 11, 2016).

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AbstractFullPdf
Nov 201608230
Dec 201605723
Total 2016013953
Jan 201703911
Feb 201701911
Mar 20170235
Apr 2017122631
May 2017112727
Jun 201751312
Jul 201731313
Aug 201792724
Sep 2017175123
Oct 2017407865
Nov 2017356136
Dec 201716387
Total 2017148415265
Jan 2018112111
Feb 2018142916
Mar 201873016
Apr 2018126234
May 201854018
Jun 2018124027
Jul 2018136026
Aug 2018125836
Sep 201898517
Oct 20181813130
Nov 20181621714
Dec 20181816811
Total 2018147941256
Jan 201991518
Feb 2019816714
Mar 2019415611
Apr 201956321
May 201923625
Jun 201974924
Jul 201923919
Aug 201954620
Oct 201933811
Nov 201932612
Dec 201943015
Total 201952801180
Jan 20203286
Feb 202032116
Mar 20200329
May 202026010
Jun 202023116
Jul 20201289
Aug 202002410
Sep 202064425
Oct 202035521
Nov 202067124
Dec 2020811123
Total 202034505169
Jan 202135110
Feb 202107311
Mar 2021126919
Apr 202147720
May 202146010
Jun 202115013
Jul 202115823
Aug 202166417
Sep 202115116
Oct 202135719
Nov 202105229
Dec 202106424
Total 202135726211
Jan 202206814
Feb 202244418
Mar 202203316
Apr 202234715
May 202215920
Jun 202219217
Jul 202234214
Aug 202204422
Sep 202243220
Oct 202213113
Nov 20223368
Dec 202265012
Total 202226578189
Jan 202324314
Feb 20230478
Mar 20230548
Apr 202305518
May 202315019
Jun 20230549
Jul 202305127
Aug 202365137
Sep 202384118
Total 202317446158
Total45945511481
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Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice
Terry C. Yin, Jaymie R. Voorhees, Rachel M. Genova, Kevin C. Davis, Ashley M. Madison, Jeremiah K. Britt, Coral J. Cintrón-Pérez, Latisha McDaniel, Matthew M. Harper, Andrew A. Pieper
eNeuro 11 October 2016, 3 (5) ENEURO.0220-16.2016; DOI: 10.1523/ENEURO.0220-16.2016

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Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice
Terry C. Yin, Jaymie R. Voorhees, Rachel M. Genova, Kevin C. Davis, Ashley M. Madison, Jeremiah K. Britt, Coral J. Cintrón-Pérez, Latisha McDaniel, Matthew M. Harper, Andrew A. Pieper
eNeuro 11 October 2016, 3 (5) ENEURO.0220-16.2016; DOI: 10.1523/ENEURO.0220-16.2016
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Keywords

  • axonal degeneration
  • nicotinamide adenine dinucleotide
  • neurodegeneration
  • traumatic brain injury
  • WldS mouse

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