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Research ArticleNew Research, Integrative Systems

Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments

Duncan A. A. MacLaren, Richard W. Browne, Jessica K. Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A. España and Stewart D. Clark
eNeuro 13 October 2016, 3 (5) ENEURO.0219-16.2016; https://doi.org/10.1523/ENEURO.0219-16.2016
Duncan A. A. MacLaren
1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
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Richard W. Browne
2Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
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Jessica K. Shaw
3Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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  • ORCID record for Jessica K. Shaw
Sandhya Krishnan Radhakrishnan
2Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
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Prachi Khare
2Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
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Rodrigo A. España
3Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
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Stewart D. Clark
1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0219-16.2016
PubMed 
27822508
Published By 
Society for Neuroscience
History 
  • Received July 28, 2016
  • Revision received October 6, 2016
  • Accepted October 6, 2016
  • Published online October 13, 2016.
Copyright & Usage 
Copyright © 2016 MacLaren et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Duncan A. A. MacLaren1,
  2. Richard W. Browne2,
  3. Jessica K. Shaw3,
  4. Sandhya Krishnan Radhakrishnan2,
  5. Prachi Khare2,
  6. Rodrigo A. España3 and
  7. Stewart D. Clark1
  1. 1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
  2. 2Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY, Buffalo, New York 14214
  3. 3Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
  1. Correspondence should be addressed to Stewart D. Clark, BRB 617, South Campus, Pharmacology and Toxicology Department, Jacob’s School of Medicine and Biological Sciences, University at Buffalo, 3435 Main Street, Buffalo, NY 14214. E-mail: stewartc{at}buffalo.edu.
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Author contributions

  1. Author contributions: D.A.A.M., R.W.B., R.A.E., and S.D.C. designed research; D.A.A.M., R.W.B., J.K.S., S.K.R., and P.K. performed research; D.A.A.M., R.W.B., J.K.S., R.A.E., and S.D.C. analyzed data; and D.A.A.M., R.W.B., R.A.E., and S.D.C. wrote the paper.

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Disclosures

  • The authors declare no competing financial interests.

  • The studies were funded by start-up funds provided to S.D.C. by The State University of New York at Buffalo and by National Institutes of Health Grant R01-DA-031900 to R.A.E .

Funding

  • University at Buffalo, SUNY

    start-up funds
  • NIH-NIDA

    R01 DA025279

Other Version

  • You are viewing the most recent version of this article.
  • previous version (October 13, 2016).

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Apr 20251516253
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Total 20251381179332
Total3126222568947
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September/October 2016
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Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments
Duncan A. A. MacLaren, Richard W. Browne, Jessica K. Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A. España, Stewart D. Clark
eNeuro 13 October 2016, 3 (5) ENEURO.0219-16.2016; DOI: 10.1523/ENEURO.0219-16.2016

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Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments
Duncan A. A. MacLaren, Richard W. Browne, Jessica K. Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A. España, Stewart D. Clark
eNeuro 13 October 2016, 3 (5) ENEURO.0219-16.2016; DOI: 10.1523/ENEURO.0219-16.2016
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    • Abstract
    • Significance Statement
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Keywords

  • behavior
  • CNO
  • DREADDs
  • voltammetry

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