High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

Jianmin Zhang; Huaishan Wang; Omar Sherbini; Emily Ling-lin Pai; Sung-Ung Kang; Ji-Sun Kwon; Jia Yang; Wei He; Hong Wang; Stephen M. Eacker; Zhikai Chi; Xiaobo Mao; Jinchong Xu; Haisong Jiang; Shaida A. Andrabi; Ted M. Dawson; Valina L. Dawson

doi:10.1523/ENEURO.0185-16.2016

Research ArticleNew Research, Disorders of the Nervous System

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

Jianmin Zhang, Huaishan Wang, Omar Sherbini, Emily Ling-lin Pai, Sung-Ung Kang, Ji-Sun Kwon, Jia Yang, Wei He, Hong Wang, Stephen M. Eacker, Zhikai Chi, Xiaobo Mao, Jinchong Xu, Haisong Jiang, Shaida A. Andrabi, Ted M. Dawson and Valina L. Dawson

eNeuro 7 October 2016, 3 (5) ENEURO.0185-16.2016; DOI: https://doi.org/10.1523/ENEURO.0185-16.2016

Jianmin Zhang

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

3Department of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, 100005, China

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jianmin Zhang

Huaishan Wang

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Omar Sherbini

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Emily Ling-lin Pai

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sung-Ung Kang

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sung-Ung Kang

Ji-Sun Kwon

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jia Yang

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jia Yang

Wei He

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hong Wang

4Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stephen M. Eacker

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Stephen M. Eacker

Zhikai Chi

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xiaobo Mao

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xiaobo Mao

Jinchong Xu

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Haisong Jiang

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shaida A. Andrabi

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ted M. Dawson

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

4Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205

6Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ted M. Dawson

Valina L. Dawson

1Neuroregeneration Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

4Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205

5Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Valina L. Dawson

Article
Figures & Data
Info & Metrics
eLetters
PDF

Published eLetters

Guidelines

As a forum for professional feedback, submissions of letters are open to all. You do not need to be a subscriber. To avoid redundancy, we urge you to read other people's letters before submitting your own. Name, current appointment, place of work, and email address are required to send a letter, and will be published with your review. We also require that you declare any competing financial interests. Unprofessional submissions will not be considered or responded to.

Submit a Response to This Article

Compose eLetter

Title *

Contents

More information about text formats

Plain text

No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First Name and Middle Initial * First or given name, e.g. 'Peter'. Last Name * Your last, or family, name, e.g. 'MacMoody'. Email Address * Your email address, e.g. higgs-boson@gmail.com Occupation * Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation * Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests? *

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Math question * 4 + 2 =

Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.

In this issue

eNeuro

Vol. 3, Issue 5

September/October 2016

Table of Contents
Index by author

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

Message Subject (Your Name) has forwarded a page to you from eNeuro

Message Body (Your Name) thought you would be interested in this article in eNeuro.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

View Full Page PDF

Citation Tools

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

eNeuro 7 October 2016, 3 (5) ENEURO.0185-16.2016; DOI: 10.1523/ENEURO.0185-16.2016

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Respond to this article

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

eNeuro 7 October 2016, 3 (5) ENEURO.0185-16.2016; DOI: 10.1523/ENEURO.0185-16.2016

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Jump to section

Article
Figures & Data
Info & Metrics
eLetters
PDF

Keywords

excitotoxicity
ischemia
library screen
stroke

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Cited By...

New Research

Allopregnanolone effects on inhibition in hippocampal parvalbumin interneurons
LINCs are vulnerable to epileptic insult and fail to provide seizure control via on-demand activation
Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia

Show more New Research

Disorders of the Nervous System

LINCs are vulnerable to epileptic insult and fail to provide seizure control via on-demand activation
Brain FNDC5/irisin expression in patients and mouse models of major depression
Increased physiological GDNF levels have no effect on dopamine neuron protection and restoration in a proteasome inhibition mouse model of Parkinson's disease

Show more Disorders of the Nervous System

Subjects

Disorders of the Nervous System

Main menu

User menu

Search

High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death

Published eLetters

Guidelines

Plain text

Vertical Tabs

Jump to comment:

In this issue

Citation Manager Formats

Keywords

Responses to this article

Jump to comment:

Related Articles

Cited By...

More in this TOC Section

New Research

Disorders of the Nervous System

Subjects