Research ArticleNew Research, Disorders of the Nervous System

Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5

Luis A. Martinez, Kellie S. Gross, Brett T. Himmler, Nicole L. Emmitt, Brittni M. Peterson, Natalie E. Zlebnik, M. Foster Olive, Marilyn E. Carroll, Robert L. Meisel and Paul G. Mermelstein
eNeuro 14 October 2016, 3 (5) ENEURO.0140-16.2016; https://doi.org/10.1523/ENEURO.0140-16.2016

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0140-16.2016
PubMed 
27822496
Published By 
Society for Neuroscience
History 
  • Received May 26, 2016
  • Revision received October 7, 2016
  • Accepted October 7, 2016
  • Published online October 14, 2016.
Copyright & Usage 
Copyright © 2016 Martinez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Luis A. Martinez1,
  2. Kellie S. Gross1,2,
  3. Brett T. Himmler1,
  4. Nicole L. Emmitt3,
  5. Brittni M. Peterson1,2,
  6. Natalie E. Zlebnik4,
  7. M. Foster Olive5,
  8. Marilyn E. Carroll2,6,
  9. Robert L. Meisel1,2 and
  10. Paul G. Mermelstein1,2
  1. 1Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455
  2. 2Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455
  3. 3College of Veterinary Medicine and Doctor of Veterinary Medicine Program, University of Minnesota, Minneapolis, MN 55455
  4. 4Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, 21201
  5. 5Department of Psychology and Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ 85287
  6. 6Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455
  1. Correspondence should be addressed to Paul G. Mermelstein, Department of Neuroscience, 6-145 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455. E-mail: pmerm{at}umn.edu.

  • Luis A. Martinez’s present address: Neuroscience Program, Trinity College, 300 Summit St., Hartford, CT 06106, USA.

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Author contributions

  1. Author Contributions: L.A.M., K.S.G., N.E.Z., M.F.O., M.E.C., R.L.M., and P.G.M. designed research; L.A.M., K.S.G., B.T.H., N.L.E., and B.M.P. performed research; L.A.M., K.S.G., B.M.P., and P.G.M. analyzed data; L.A.M. and P.G.M. wrote the paper.

  • Luis A. Martinez’s present address: Neuroscience Program, Trinity College, 300 Summit St., Hartford, CT 06106, USA.

Disclosures

  • Authors report no conflict of interest.

  • This research was supported by National Institutes of Health grants DA035008 (R.L.M. and P.G.M.), DA035008-S1 (L.A.M. and P.G.M.), DA024355 (M.F.O.), and T32DA007234 (L.A.M., K.S.G., and B.T.H.).

Funding

  • National Institute on Drug Addiction

    DA035008

  • National Institute on Drug Addiction

    DA035008-S1

  • National Institute on Drug Addiction

    DA024355

  • National Institute of Neurological Disorders and Stroke

    NS062158

  • National Insititute on Drug Addiction

    T32DA007234

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Total54685291585
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eneuro: 3 (5)
eNeuro
Vol. 3, Issue 5
September/October 2016
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Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5
Luis A. Martinez, Kellie S. Gross, Brett T. Himmler, Nicole L. Emmitt, Brittni M. Peterson, Natalie E. Zlebnik, M. Foster Olive, Marilyn E. Carroll, Robert L. Meisel, Paul G. Mermelstein
eNeuro 14 October 2016, 3 (5) ENEURO.0140-16.2016; DOI: 10.1523/ENEURO.0140-16.2016
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  • Published on: (30 January 2017)
    Page navigation anchor for RE: Sex differences in the vulnerability to addiction.
    RE: Sex differences in the vulnerability to addiction.
    • Aldo Badiani, Professor of Addiction Medicine, Sussex Addiction Research and Intervention Centre (SARIC), University of Sussex

    This article opens with the following statement: "Although drug addiction affects both sexes, addiction develops and progresses more rapidly in females compared with males." However, no evidence is provided in support of this statement and it is disconcerting that this oversight passed the review process unscathed.
    Actually, available evidence show exactly the opposite, that is, men are much more likely to develop addiction than women (e.g., Grant et al., Mol Psychiatry, 2009; Compton et al., Am J Psychiatry, 2013; Kendler et al., Am J Psychiatry, 2014). Indeed, the existence of different rates of drug addiction in males versus females is common knowledge among medical and non-medical staff working in the field of substance misuse.

    Competing Interests: None declared.

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