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Research ArticleNew Research, Disorders of the Nervous System

Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome

Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame and Mara Dierssen
eNeuro 19 October 2016, 3 (5) ENEURO.0103-16.2016; https://doi.org/10.1523/ENEURO.0103-16.2016
Silvina Catuara-Solarz
1Cellular and Systems Neurobiology, Systems Biology Program, the Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), 08003, Barcelona, Spain
2Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
3Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, 08003, Spain
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Jose Espinosa-Carrasco
1Cellular and Systems Neurobiology, Systems Biology Program, the Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), 08003, Barcelona, Spain
2Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
4Comparative Bioinformatics, Bioinformatics, and Genomics Program, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Barcelona, 08003, Spain
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Ionas Erb
2Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
4Comparative Bioinformatics, Bioinformatics, and Genomics Program, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Barcelona, 08003, Spain
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Klaus Langohr
3Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, 08003, Spain
5Department of Statistics and Operations Research, Universitat Politècnica De Catalunya/BarcelonaTech, Barcelona, 08034, Spain
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Juan Ramon Gonzalez
6Centre for Research in Environmental Epidemiology, Barcelona, 08003, Spain
7Centro De Investigación Biomédica En Red De Epidemiología Y Salud Pública, Madrid, 28029, Spain
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Cedric Notredame
2Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
4Comparative Bioinformatics, Bioinformatics, and Genomics Program, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Barcelona, 08003, Spain
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Mara Dierssen
1Cellular and Systems Neurobiology, Systems Biology Program, the Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), 08003, Barcelona, Spain
3Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, 08003, Spain
8Centro De Investigación Biomédica En Red De Enfermedades Raras, Madrid, 28029, Spain
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Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
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Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
eNeuro 19 October 2016, 3 (5) ENEURO.0103-16.2016; DOI: 10.1523/ENEURO.0103-16.2016

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Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
eNeuro 19 October 2016, 3 (5) ENEURO.0103-16.2016; DOI: 10.1523/ENEURO.0103-16.2016
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Keywords

  • (-)-epigallocatechin-3-gallate
  • Down syndrome
  • environmental enrichment
  • Excitation-Inhibition Imbalance
  • neuroplasticity

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