Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Haisong Jiang; Sung-Ung Kang; Shuran Zhang; Senthilkumar Karuppagounder; Jinchong Xu; Yong-Kyu Lee; Bong-Gu Kang; Yunjong Lee; Jianmin Zhang; Olga Pletnikova; Juan C. Troncoso; Shelia Pirooznia; Shaida A. Andrabi; Valina L. Dawson; Ted M. Dawson

doi:10.1523/ENEURO.0183-16.2016

Research ArticleNew Research, Disorders of the Nervous System

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C. Troncoso, Shelia Pirooznia, Shaida A. Andrabi, Valina L. Dawson and Ted M. Dawson

eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; https://doi.org/10.1523/ENEURO.0183-16.2016

Haisong Jiang

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

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Sung-Ung Kang

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

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Shuran Zhang

5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Senthilkumar Karuppagounder

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

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Jinchong Xu

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Yong-Kyu Lee

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Bong-Gu Kang

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Yunjong Lee

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

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Jianmin Zhang

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Olga Pletnikova

7Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Juan C. Troncoso

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

7Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Shelia Pirooznia

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

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Shaida A. Andrabi

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Valina L. Dawson

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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Ted M. Dawson

1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685

4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685

5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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ORCID record for Ted M. Dawson

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Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; DOI: 10.1523/ENEURO.0183-16.2016

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Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; DOI: 10.1523/ENEURO.0183-16.2016

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Keywords

dopamine neuron
mitochondria
neurodegeneration
PGC-1α
substantia nigra

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