Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT

User menu

Search

  • Advanced search
eNeuro
eNeuro

Advanced Search

 

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Blog
    • Collections
    • Podcast
  • TOPICS
    • Cognition and Behavior
    • Development
    • Disorders of the Nervous System
    • History, Teaching and Public Awareness
    • Integrative Systems
    • Neuronal Excitability
    • Novel Tools and Methods
    • Sensory and Motor Systems
  • ALERTS
  • FOR AUTHORS
  • ABOUT
    • Overview
    • Editorial Board
    • For the Media
    • Privacy Policy
    • Contact Us
    • Feedback
  • SUBMIT
PreviousNext
Research ArticleNew Research, Disorders of the Nervous System

Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons

Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C. Troncoso, Shelia Pirooznia, Shaida A. Andrabi, Valina L. Dawson and Ted M. Dawson
eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; https://doi.org/10.1523/ENEURO.0183-16.2016
Haisong Jiang
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sung-Ung Kang
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sung-Ung Kang
Shuran Zhang
5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Senthilkumar Karuppagounder
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jinchong Xu
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong-Kyu Lee
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yong-Kyu Lee
Bong-Gu Kang
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bong-Gu Kang
Yunjong Lee
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yunjong Lee
Jianmin Zhang
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jianmin Zhang
Olga Pletnikova
7Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juan C. Troncoso
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
7Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shelia Pirooznia
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shaida A. Andrabi
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Valina L. Dawson
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Valina L. Dawson
Ted M. Dawson
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ted M. Dawson
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/ENEURO.0183-16.2016
PubMed 
27622213
Published By 
Society for Neuroscience
History 
  • Received June 28, 2016
  • Revision received August 8, 2016
  • Accepted August 10, 2016
  • Published online August 15, 2016.
Copyright & Usage 
Copyright © 2016 Jiang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Haisong Jiang1,2,3,4,*,
  2. Sung-Ung Kang1,2,3,4,*,
  3. Shuran Zhang5,
  4. Senthilkumar Karuppagounder1,2,3,4,
  5. Jinchong Xu1,2,
  6. Yong-Kyu Lee1,2,
  7. Bong-Gu Kang1,2,
  8. Yunjong Lee1,6,3,4,
  9. Jianmin Zhang1,2,
  10. Olga Pletnikova7,
  11. Juan C. Troncoso2,7,
  12. Shelia Pirooznia1,2,3,4,
  13. Shaida A. Andrabi1,2,
  14. Valina L. Dawson1,2,3,4,5,6 and
  15. Ted M. Dawson1,2,3,4,5,8
  1. 1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  2. 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  3. 3Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685
  4. 4Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130-2685
  5. 5Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  6. 6Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  7. 7Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  8. 8Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
  1. Correspondence should be addressed to either Valina L. Dawson or Ted M. Dawson, Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, E-mail: vdawson{at}jhmi.edu or tdawson{at}jhmi.edu.
  • Y. Lee’s present address: Division of Pharmacology, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 440-746, South Korea.

  • J. Zhang’s present address: Department of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, People’s Republic of China.

View Full Text

Author contributions

  1. Author contributions: H.J., S.-U.K., V.L.D., and T.M.D. designed the research; H.J., S.-U.K., S.Z., S.K., J.X., Y.-K.L., B.-G.K., Y.L., J.Z., and S.A.A. performed research; O.P. and J.C.T. contributed unpublished reagents/analytic tools; H.J., S.-U.K., S.Z., S.K., J.X., Y.-K.L., B.-G.K., Y.L., J.Z., and S.A.A. analyzed data; H.J., S.-U.K., S.P., V.L.D., and T.M.D. wrote the paper.

  2. ↵* H.J. and S.-U.K. contributed equally to this work.

  • Y. Lee’s present address: Division of Pharmacology, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 440-746, South Korea.

  • J. Zhang’s present address: Department of Immunology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing 100005, People’s Republic of China.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by National Institutes of Health/National Institute of Neurological Disorders and Stroke Grant NS038377, the JPB Foundation, the Adrienne Helis Malvin Medical Research Foundation, and the Diana Helis Henry Medical Research Foundation. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases.

Funding

  • NIH NINDS

    NS38377
  • JBP Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 15, 2016).

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2026-03-16
to
E.g., 2026-03-16

Article usage: September 2016 to March 2026

AbstractFullPdf
Sep 2016010435
Oct 201609844
Nov 201604613
Dec 20160499
Total 20160297101
Jan 201703422
Feb 201703411
Mar 201705014
Apr 201782629
May 2017123635
Jun 2017111617
Jul 2017163029
Aug 201774545
Sep 2017194844
Oct 2017397042
Nov 20175010772
Dec 2017205523
Total 2017182551383
Jan 2018304622
Feb 2018223730
Mar 2018225820
Apr 2018168058
May 2018197123
Jun 2018128168
Jul 2018145221
Aug 2018197762
Sep 201893625
Oct 20188859
Nov 20181813817
Dec 20181424721
Total 20182031008376
Jan 201931058
Feb 20191313812
Mar 2019419419
Apr 2019818120
May 2019512710
Jun 2019811412
Jul 2019419825
Aug 2019528811
Oct 2019831621
Nov 2019322021
Dec 2019915234
Total 2019702033193
Jan 202024620
Feb 202024731
Mar 202002611
May 202035930
Jun 20202264
Jul 202033015
Aug 202072028
Sep 20202239
Oct 202076524
Nov 202058417
Dec 202088310
Total 202041509199
Jan 2021410017
Feb 20211645
Mar 202118718
Apr 202145711
May 202137514
Jun 202116316
Jul 202137513
Aug 202139817
Sep 202116320
Oct 2021310638
Nov 202106018
Dec 202107410
Total 202124922197
Jan 2022310216
Feb 20225669
Mar 202229915
Apr 20223999
May 2022311011
Jun 2022111811
Jul 2022310311
Aug 2022257413
Sep 2022155716
Oct 202225020
Nov 202244116
Dec 202264312
Total 202272962159
Jan 202317424
Feb 20235469
Mar 202346111
Apr 202305913
May 202384923
Jun 20232475
Jul 202345727
Aug 202355425
Sep 202386116
Oct 202336110
Nov 2023105917
Dec 2023288547
Total 202378713227
Jan 202496416
Feb 2024105413
Mar 202436718
Apr 20241414529
May 202465722
Jun 202466022
Jul 202495620
Aug 202485918
Sep 2024105019
Oct 202446414
Nov 202446113
Dec 202456826
Total 202488805230
Jan 202587526
Feb 2025178221
Mar 202579533
Apr 202548025
May 202577318
Jun 20251711334
Jul 202599136
Aug 2025711343
Sep 20251415032
Oct 20251014429
Nov 20251813033
Dec 20252314343
Total 20251411289373
Jan 20262614833
Feb 20263725626
Mar 202634718
Total 20266645177
Total96595402515
Back to top

In this issue

eneuro: 3 (4)
eNeuro
Vol. 3, Issue 4
July/August 2016
  • Table of Contents
  • Index by author
Email

Thank you for sharing this eNeuro article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
(Your Name) has forwarded a page to you from eNeuro
(Your Name) thought you would be interested in this article in eNeuro.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C. Troncoso, Shelia Pirooznia, Shaida A. Andrabi, Valina L. Dawson, Ted M. Dawson
eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; DOI: 10.1523/ENEURO.0183-16.2016

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Share
Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C. Troncoso, Shelia Pirooznia, Shaida A. Andrabi, Valina L. Dawson, Ted M. Dawson
eNeuro 15 August 2016, 3 (4) ENEURO.0183-16.2016; DOI: 10.1523/ENEURO.0183-16.2016
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • Significance Statement
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
    • Synthesis
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • dopamine neuron
  • mitochondria
  • neurodegeneration
  • PGC-1α
  • substantia nigra

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

New Research

  • A Very Fast Time Scale of Human Motor Adaptation: Within Movement Adjustments of Internal Representations during Reaching
  • Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses
  • TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons
Show more New Research

Disorders of the Nervous System

  • Numbers of granule cells and GABAergic boutons are correlated in shrunken sclerotic hippocampi of sea lions with temporal lobe epilepsy
  • Investigating the Role of Cortical Microglia in a Mouse Model of Viral Infection-Induced Seizures
  • Functional-Structural Coupling: Brain Reorganization in Presbycusis Is Related to Cognitive Impairment
Show more Disorders of the Nervous System

Subjects

  • Disorders of the Nervous System
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Latest Articles
  • Issue Archive
  • Blog
  • Browse by Topic

Information

  • For Authors
  • For the Media

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Feedback
(eNeuro logo)
(SfN logo)

Copyright © 2026 by the Society for Neuroscience.
eNeuro eISSN: 2373-2822

The ideas and opinions expressed in eNeuro do not necessarily reflect those of SfN or the eNeuro Editorial Board. Publication of an advertisement or other product mention in eNeuro should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in eNeuro.