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Research ArticleMethods/New Tools, Novel Tools and Methods

LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition

Julia Brill, Joanna Mattis, Karl Deisseroth and John R. Huguenard
eNeuro 21 July 2016, 3 (4) ENEURO.0142-15.2016; https://doi.org/10.1523/ENEURO.0142-15.2016
Julia Brill
1Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305
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Joanna Mattis
2Department of Bioengineering, Stanford University, Stanford, California 94305
3Neuroscience Program, Stanford University, Stanford, California 94305
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Karl Deisseroth
2Department of Bioengineering, Stanford University, Stanford, California 94305
4CNC Program, Stanford University, Stanford, California 94305
5Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305
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John R. Huguenard
1Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0142-15.2016
PubMed 
27517089
Published By 
Society for Neuroscience
History 
  • Received November 23, 2015
  • Revision received June 28, 2016
  • Accepted July 15, 2016
  • Published online July 21, 2016.
Copyright & Usage 
Copyright © 2016 Brill et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Julia Brill1,
  2. Joanna Mattis2,3,
  3. Karl Deisseroth2,4,5 and
  4. John R. Huguenard1
  1. 1Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305
  2. 2Department of Bioengineering, Stanford University, Stanford, California 94305
  3. 3Neuroscience Program, Stanford University, Stanford, California 94305
  4. 4CNC Program, Stanford University, Stanford, California 94305
  5. 5Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305
  1. Correspondence should be addressed to John R. Huguenard, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1050A Arastradero Road, Room A250, Palo Alto, CA 94304. E-mail: john.huguenard{at}stanford.edu.
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Author contributions

  1. Author contributions: J.B. and J.R.H. designed research; J.B., J.M., and J.R.H. performed research; K.D. contributed unpublished reagents; J.B., J.M., and J.R.H. analyzed data; J.B., J.M., and J.R.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This research was supported by National Institutes of Health Grants NS-034774, NS-006477, and NS-012151.

Funding

  • NIH - NINDS

    NS034774
  • NIH - NINDS

    NS006477
  • NIH - NINDS

    NS012151

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  • You are viewing the most recent version of this article.
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Total52448831655
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LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition
Julia Brill, Joanna Mattis, Karl Deisseroth, John R. Huguenard
eNeuro 21 July 2016, 3 (4) ENEURO.0142-15.2016; DOI: 10.1523/ENEURO.0142-15.2016

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LSPS/Optogenetics to Improve Synaptic Connectivity Mapping: Unmasking the Role of Basket Cell-Mediated Feedforward Inhibition
Julia Brill, Joanna Mattis, Karl Deisseroth, John R. Huguenard
eNeuro 21 July 2016, 3 (4) ENEURO.0142-15.2016; DOI: 10.1523/ENEURO.0142-15.2016
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Keywords

  • connectivity mapping
  • laser-scanning photostimulation
  • neocortex
  • Optogenetics
  • parvalbumin
  • pyramidal cells

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