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Research ArticleNew Research, Neuronal Excitability

Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus

Alexandre Guet-McCreight, Olivier Camiré, Lisa Topolnik and Frances K. Skinner
eNeuro 29 August 2016, 3 (4) ENEURO.0087-16.2016; https://doi.org/10.1523/ENEURO.0087-16.2016
Alexandre Guet-McCreight
1Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
2Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Olivier Camiré
3Department of Biochemistry, Microbiology and Bio-informatics, Neuroscience Axis, CHU de Québec Research Center (CHUL), Laval University, Québec City, Québec, G1V 0A6, Canada
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Lisa Topolnik
3Department of Biochemistry, Microbiology and Bio-informatics, Neuroscience Axis, CHU de Québec Research Center (CHUL), Laval University, Québec City, Québec, G1V 0A6, Canada
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Frances K. Skinner
1Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
4Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0087-16.2016
PubMed 
27679813
Published By 
Society for Neuroscience
History 
  • Received April 13, 2016
  • Revision received August 19, 2016
  • Accepted August 22, 2016
  • Published online August 29, 2016.
Copyright & Usage 
Copyright © 2016 Guet-McCreight et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Alexandre Guet-McCreight1,2,
  2. Olivier Camiré3,
  3. Lisa Topolnik3 and
  4. Frances K. Skinner1,4
  1. 1Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada
  2. 2Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
  3. 3Department of Biochemistry, Microbiology and Bio-informatics, Neuroscience Axis, CHU de Québec Research Center (CHUL), Laval University, Québec City, Québec, G1V 0A6, Canada
  4. 4Departments of Medicine (Neurology) and Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
  1. Correspondence should be addressed to either of the following: Alexandre Guet-McCreight (computational correspondence), 60 Leonard Avenue, 7KD410, Toronto, ON M5T 2S8, Canada, E-mail: alexandre.guet.mccreight{at}mail.utoronto.ca; or Lisa Topolnik (experimental correspondence), 2705 Boulevard Laurier, R-3704.6, Québec, QC G1V 4G2, Canada, E-mail: lisa.topolnik{at}bcm.ulaval.ca.
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Author contributions

  1. Author contributions: A.G.-M., O.C., L.T., and F.K.S. designed research; A.G.-M. and O.C. performed research; A.G.-M., O.C., L.T., and F.K.S. analyzed data; A.G.-M., O.C., L.T., and F.K.S. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by Canadian Institutes of Health Research Grants to L.T., and Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grants to L.T. and F.K.S. O.C. was supported by the NSERC Postgraduate Scholarships-Doctoral (PGS D). A.G.-M. was supported by a NSERC Canada Graduate Scholarships-Master’s (CGS M) fellowship, the Mary H. Beatty Fellowship, the Unilever/Lipton Ontario Student Opportunity Trust Fund Graduate Fellowship, and the Queen Elizabeth II Graduate Scholarships in Science and Technology Fellowship.

Funding

  • NSERC Discovery Grant

    RGPIN-203700-2011
  • NSERC CGS-M

    CGSM-444436-2013
  • Mary H. Beatty Fellowship

    N/A
  • OSOTF Unilever/Lipton Graduate Fellowship

    N/A
  • QEII-GSST Fellowship

    N/A
  • NSERC Discovery Grant

  • CIHR

  • NSERC PhD Fellowship

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 29, 2016).

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July/August 2016
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Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus
Alexandre Guet-McCreight, Olivier Camiré, Lisa Topolnik, Frances K. Skinner
eNeuro 29 August 2016, 3 (4) ENEURO.0087-16.2016; DOI: 10.1523/ENEURO.0087-16.2016

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Using a Semi-Automated Strategy to Develop Multi-Compartment Models That Predict Biophysical Properties of Interneuron-Specific 3 (IS3) Cells in Hippocampus
Alexandre Guet-McCreight, Olivier Camiré, Lisa Topolnik, Frances K. Skinner
eNeuro 29 August 2016, 3 (4) ENEURO.0087-16.2016; DOI: 10.1523/ENEURO.0087-16.2016
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Keywords

  • hippocampus
  • interneuron
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