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Research ArticleNew Research, Sensory and Motor Systems

The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type

Matthew T. Kaufman, Jeffrey S. Seely, David Sussillo, Stephen I. Ryu, Krishna V. Shenoy and Mark M. Churchland
eNeuro 3 August 2016, 3 (4) ENEURO.0085-16.2016; https://doi.org/10.1523/ENEURO.0085-16.2016
Matthew T. Kaufman
1Neurosciences Program, Stanford University, Stanford, California 94305
2Department of Electrical Engineering, Stanford University, Stanford, California 94305
5Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
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  • ORCID record for Matthew T. Kaufman
Jeffrey S. Seely
6Department of Neuroscience
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David Sussillo
1Neurosciences Program, Stanford University, Stanford, California 94305
2Department of Electrical Engineering, Stanford University, Stanford, California 94305
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Stephen I. Ryu
2Department of Electrical Engineering, Stanford University, Stanford, California 94305
8Department of Neurosurgery, Palo Alto Medical Foundation, Palo Alto, California 94301
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Krishna V. Shenoy
1Neurosciences Program, Stanford University, Stanford, California 94305
2Department of Electrical Engineering, Stanford University, Stanford, California 94305
3Department of Bioengineering, Stanford University, Stanford, California 94305
4Department of Neurobiology, Stanford University, Stanford, California 94305
9Howard Hughes Medical Institute, Stanford University, Stanford, California 94305
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Mark M. Churchland
6Department of Neuroscience
7Grossman Center for the Statistics of Mind, David Mahoney Center for Brain and Behavior Research, Kavli Institute for Brain Science, Columbia University Medical Center, New York, NY 10032
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0085-16.2016
PubMed 
27761519
Published By 
Society for Neuroscience
History 
  • Received April 18, 2016
  • Revision received July 31, 2016
  • Accepted August 1, 2016
  • Published online August 3, 2016.
Copyright & Usage 
Copyright © 2016 Kaufman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Matthew T. Kaufman1,2,5,
  2. Jeffrey S. Seely6,
  3. David Sussillo1,2,
  4. Stephen I. Ryu2,8,
  5. Krishna V. Shenoy1,2,3,4,9 and
  6. Mark M. Churchland6,7
  1. 1Neurosciences Program, Stanford University, Stanford, California 94305
  2. 2Department of Electrical Engineering, Stanford University, Stanford, California 94305
  3. 3Department of Bioengineering, Stanford University, Stanford, California 94305
  4. 4Department of Neurobiology, Stanford University, Stanford, California 94305
  5. 5Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
  6. 6Department of Neuroscience
  7. 7Grossman Center for the Statistics of Mind, David Mahoney Center for Brain and Behavior Research, Kavli Institute for Brain Science, Columbia University Medical Center, New York, NY 10032
  8. 8Department of Neurosurgery, Palo Alto Medical Foundation, Palo Alto, California 94301
  9. 9Howard Hughes Medical Institute, Stanford University, Stanford, California 94305
  1. Correspondence should be addressed to Mark Churchland, Kolb Research Annex, 40 Haven Avenue, New York, NY 10032-2652. E-mail: mc3502{at}columbia.edu
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Author contributions

  1. Author contributions: M.T.K., K.V.S., and M.M.C. designed research; M.T.K. and M.M.C. performed research; M.T.K. analyzed data; M.T.K. and M.M.C. wrote the paper; J.S.S., D.S., and S.R. contributed unpublished reagents/analytic tools.

Disclosures

  • The authors report no conflict of interest.

Funding

  • Grossman Charitable Trust

  • National Science Foundation

  • Swartz Foundation

  • Burroughs Wellcome Fund

  • NIH Director's Office

    1DP1OD006409
  • DARPA REPAIR

    N66001-10-C-2010
  • NIH Director's Office

  • Searle Scholars Foundation

  • Sloan Research Foundation

  • McKnight Foundation

  • Simons Foundation

  • Esther A. & Joseph Klingenstein Fund

Other Version

  • You are viewing the most recent version of this article.
  • previous version (August 03, 2016).

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Total1649159753749
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The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type
Matthew T. Kaufman, Jeffrey S. Seely, David Sussillo, Stephen I. Ryu, Krishna V. Shenoy, Mark M. Churchland
eNeuro 3 August 2016, 3 (4) ENEURO.0085-16.2016; DOI: 10.1523/ENEURO.0085-16.2016

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The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type
Matthew T. Kaufman, Jeffrey S. Seely, David Sussillo, Stephen I. Ryu, Krishna V. Shenoy, Mark M. Churchland
eNeuro 3 August 2016, 3 (4) ENEURO.0085-16.2016; DOI: 10.1523/ENEURO.0085-16.2016
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Keywords

  • condition-invariant signal
  • dPCA
  • Movement initiation
  • Movement triggering
  • reaction time
  • State space

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