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Research ArticleNew Research, Development

Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent

Melissa R. Andrews, Sara Soleman, Menghon Cheah, David A. Tumbarello, Matthew R. J. Mason, Elizabeth Moloney, Joost Verhaagen, Jean-Charles Bensadoun, Bernard Schneider, Patrick Aebischer and James W. Fawcett
eNeuro 7 July 2016, 3 (4) ENEURO.0029-16.2016; DOI: https://doi.org/10.1523/ENEURO.0029-16.2016
Melissa R. Andrews
1School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom
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Sara Soleman
2Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, CB2 0PY, United Kingdom
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Menghon Cheah
2Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, CB2 0PY, United Kingdom
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David A. Tumbarello
3Biological Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, United Kingdom
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Matthew R. J. Mason
4Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Meibergdreef 47, Amsterdam 1105BA, The Netherlands
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Elizabeth Moloney
4Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Meibergdreef 47, Amsterdam 1105BA, The Netherlands
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Joost Verhaagen
4Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Meibergdreef 47, Amsterdam 1105BA, The Netherlands
5Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognition research, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands
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Jean-Charles Bensadoun
6Neurodegenerative Disease Laboratory, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
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Bernard Schneider
6Neurodegenerative Disease Laboratory, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
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Patrick Aebischer
6Neurodegenerative Disease Laboratory, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
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James W. Fawcett
2Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, CB2 0PY, United Kingdom
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0029-16.2016
PubMed 
27570822
Published By 
Society for Neuroscience
History 
  • Received February 15, 2016
  • Revision received June 27, 2016
  • Accepted June 29, 2016
  • Published online July 7, 2016.
Copyright & Usage 
Copyright © 2016 Andrews et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Melissa R. Andrews1,
  2. Sara Soleman2,
  3. Menghon Cheah2,
  4. David A. Tumbarello3,
  5. Matthew R. J. Mason4,
  6. Elizabeth Moloney4,
  7. Joost Verhaagen4,5,
  8. Jean-Charles Bensadoun6,
  9. Bernard Schneider6,
  10. Patrick Aebischer6 and
  11. James W. Fawcett2
  1. 1School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom
  2. 2Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, CB2 0PY, United Kingdom
  3. 3Biological Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, United Kingdom
  4. 4Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Meibergdreef 47, Amsterdam 1105BA, The Netherlands
  5. 5Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognition research, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands
  6. 6Neurodegenerative Disease Laboratory, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
  1. Correspondence should be addressed to either of the following: James W. Fawcett, Brain Repair Centre, Robinson Way, Cambridge CB2 0PY, UK, E-mail: jf108{at}cam.ac.uk; or Melissa R. Andrews, School of Medicine, University of St Andrews, Medical and Biological Sciences Builldingg, North Haugh, St Andrews, KY16 9TF, UK, E-mail: mra5{at}st-andrews.ac.uk.
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Author contributions

  1. Author contributions: M.R.A. and J.W.F. designed research; M.R.A., M.C., S.S., D.A.T. performed research; M.R.J.M., E.M., J.V., J.-C.B., B.S., P.A. contributed unpublished reagents and tools; M.R.A. and J.W.F. analyzed data; M.R.A. and J.W.F. wrote the paper.

Disclosures

  • James Fawcett is a paid consultant for Acorda Therapeutics.

  • This work was supported by the International Foundation for Research in Paraplegia (M.R.A.), the Bryon Riesch Paralysis Foundation (M.R.A.), the American Association of Anatomists (M.R.A.), the Christopher and Dana Reeve Foundation (J.W.F.), the Medical Research Council (J.W.F.), the Plasticise European Network (seventh framework program; J.W.F.) and the NIHR Cambridge Biomedical Research Centre. We thank Dr. Natalie Bull (University of Cambridge) for assistance with intravitreal injections.

Funding

  • International Foundation for Research In Paraplegia

    P117
  • American Association of Anatomists

  • Bryon Riesch Paralysis Foundation

  • Christopher and Dana Reeve Foundation

  • Plasticise European Network (7th Framework programme)

  • NIHR Cambridge Biomedical Research Centre

Other Version

  • You are viewing the most recent version of this article.
  • previous version (July 07, 2016).

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Aug 20160183
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Total 20181061262272
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Total 2019661017174
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Feb 202063525
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Total 2023214376
Total44551081504
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Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent
Melissa R. Andrews, Sara Soleman, Menghon Cheah, David A. Tumbarello, Matthew R. J. Mason, Elizabeth Moloney, Joost Verhaagen, Jean-Charles Bensadoun, Bernard Schneider, Patrick Aebischer, James W. Fawcett
eNeuro 7 July 2016, 3 (4) ENEURO.0029-16.2016; DOI: 10.1523/ENEURO.0029-16.2016

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Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent
Melissa R. Andrews, Sara Soleman, Menghon Cheah, David A. Tumbarello, Matthew R. J. Mason, Elizabeth Moloney, Joost Verhaagen, Jean-Charles Bensadoun, Bernard Schneider, Patrick Aebischer, James W. Fawcett
eNeuro 7 July 2016, 3 (4) ENEURO.0029-16.2016; DOI: 10.1523/ENEURO.0029-16.2016
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Keywords

  • adeno-associated virus
  • axon initial segment
  • dorsal root ganglia
  • integrin
  • retinal ganglion cell
  • sensorimotor cortex

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