a |
Fig. 1D | Two factors (day and treatment) | Two-way ANOVA with repeated measures | n = 10 mice | Day: F(4,72) = 3.752, p = 0.0079Treatment: F(1,18) = 31.50, p < 0.0001Interaction: F(4,72) = 2.639, p = 0.0407Sidak's multiple comparisons test:Saline vs drug, day 1: p = 0.2737Saline vs drug, day 2: p = 0.0630Saline vs drug, day 3: p = 0.0003Saline vs drug, day 4: p < 0.0001Saline vs drug, day 5: p < 0.0001 |
b |
Fig. 1E | Two factors (day and treatment) | Two-way ANOVA with repeated measures | n = 10 mice | Day: F(4,72) = 0.8313, p = 0.5096Treatment: F(1,18) = 17.66, p = 0.0005Interaction: F(4,72) = 0.6524, p = 0.6270Sidak's multiple comparisons test:Saline vs drug, day 1: p = 0.0148Saline vs drug, day 2: p = 0.0190Saline vs drug, day 3: p = 0.0004Saline vs drug, day 4: p = 0.0013Saline vs drug, day 5: p = 0.0034 |
c |
Fig. 1F | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 10 mice | p > 0.9999 |
d |
Fig. 1G | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 10 mice | p = 0.0273 |
e |
Fig. 1H | Two variables | r and rs | n = 10 mice | r = 0.080, p = 0.827rs = −0.103, p = 0.785 |
f |
Fig. 1K | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 10 mice | p = 0.6953 |
g |
Fig. 1L | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 10 mice | p = 0.9219 |
h |
Fig. 2A | Two factors (day and treatment) | Two-way ANOVA with repeated measures | n = 7 mice | Day: F(4,48) = 1.450, p = 0.2320Treatment: F(1,12) = 0.02449, p = 0.8782Interaction: F(4,48) = 0.4431, p = 0.7768Sidak's multiple comparisons test:Day 1: p > 0.9999Day 2: p = 0.9701Day 3: p > 0.9999Day 4: p > 0.9999Day 5: p = 0.8377 |
i |
Fig. 2B | Two factors (day and treatment) | Two-way ANOVA with repeated measures | n = 7 mice | Day: F(4,48) = 1.777, p = 0.1489Treatment: F(1,12) = 0.07157, p = 0.7936Interaction: F(4,48) = 0.2804, p = 0.8893Sidak's multiple comparisons test:Day 1: p = 0.9998Day 2: p = 0.9913Day 3: p = 0.9992Day 4: p > 0.9999Day 5: p = 0.9907 |
j |
Fig. 2C | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 7 mice | p = 0.2969 |
k |
Fig. 2D | Nonparametric | Wilcoxon matched pairs signed-rank test | n = 7 mice | p = 0.3750 |
l |
Fig. 4C, left | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.4028Bonferroni’s correction: 2 comparisons,α = 0.025 |
m |
Fig. 4C, right | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.0328Bonferroni’s correction: 2 comparisons,α = 0.025 |
n |
Fig. 4D, left | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.5942Bonferroni’s correction: 2 comparisons,α = 0.025 |
o |
Fig. 4D, right | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.4705Bonferroni’s correction: 2 comparisons,α = 0.025 |
p |
Fig. 4E, left | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.9252Bonferroni’s correction: 2 comparisons,α = 0.025 |
q |
Fig. 4E, right | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.4028Bonferroni’s correction: 2 comparisons,α = 0.025 |
r |
Fig. 4F, left | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p = 0.3130Bonferroni’s correction: 2 comparisons,α = 0.025 |
s |
Fig. 4F, right | Nonparametric | Mann–Whitney test | n = 7 control group + 10 drug group | p > 0.9999Bonferroni’s correction: 2 comparisons,α = 0.025 |
t |
Fig. 4G, left | Nonparametric | Kolmogorov–Smirnov test | n = 26 control + 80 drug group FSIs | p = 0.7Bonferroni’s correction: 2 comparisons,α = 0.025 |
|
u |
Fig. 4G, right | Nonparametric | Kolmogorov–Smirnov test | n = 21 control + 60 drug group FSIs | p = 0.945Bonferroni’s correction: 2 comparisons,α = 0.025 |
v |
Fig. 4H, left | Nonparametric | Kolmogorov–Smirnov test | n = 102 control + 110 drug group FSIs | p = 0.0584Bonferroni’s correction: 2 comparisons,α = 0.025 |
w |
Fig. 4H, right | Nonparametric | Kolmogorov–Smirnov test | n = 42 control + 97 drug group FSIs | p = 0.349Bonferroni’s correction: 2 comparisons,α = 0.025 |
x |
Fig. 5E | Nonparametric | Wilcoxon matched-pairs signed rank test | n = 10 mice | p = 0.4316 |
y |
Fig. 5F | Nonparametric | Wilcoxon matched-pairs signed rank test | n = 10 mice | p = 0.6953 |
z |
Fig. 5G | Nonparametric | Wilcoxon matched-pairs signed rank test | n = 10 mice | p = 0.1602 |
aa |
Fig. 5H | Nonparametric | Wilcoxon matched-pairs signed rank test | n = 10 mice | p = 0.9102 |
ab |
Fig. 6A | Two variables | r and rs | n = 10 mice | r = 0.2132, p = 0.5543rs =0.1394, p = 0.7072 |
ac |
Fig. 6B | Two variables | r and rs | n = 10 mice | r = 0.3706, p = 0.2918rs = 0.3091, p = 0.3869 |
ad |
Fig. 6C | Two variables | r and rs | n = 10 mice | r = 0.8089, p = 0.0046rs = 0.7818, p = 0.0105 |
ae |
Fig. 6D | Two variables | r and rs | n = 10 mice | r = 0.7793, p = 0.0079rs = 0.7091, p = 0.0268 |
af |
Fig. 6E | Two variables | r and rs | n = 10 mice | r = 0.9051, p = 0.0003rs = 0.9605, p < 0.0001Bonferroni’s correction: 2 comparisons,α = 0.025 |
ag |
Fig. 6F | Two variables | r and rs | n = 10 mice | r = 0.7426, p = 0.0139rs = 0.7455, p = 0.0174Bonferroni’s correction: 2 comparisons,α = 0.025 |
ah |
Fig. 6G | Two variables | r and rs | n = 10 mice | r = 0.5701, p = 0.0853rs = 0.5152, p = 0.1334Bonferroni’s correction: 2 comparisons,α = 0.025 |
ai |
Fig. 6H | Two variables | r and rs | n = 10 mice | r = 0.8391, p = 0.0024rs = 0.7818, p = 0.0105Bonferroni’s correction: 2 comparisons,α = 0.025 |
aj |
Fig. 7A | Two variables | r and rs | n = 10 mice | r = 0.1131, p = 0.7558rs = −0.0901, p = 0.8113 |
ak |
Fig. 7B | Two variables | r and rs | n = 10 mice | r = 0.1634, p = 0.6520rs = 0.2727, p = 0.4483 |
al | Fig. 7C | Two variables | r and rs | n = 10 mice | r = −0.1255, p = 0.7297rs = −0.0909, p = 0.8113 |
am |
Fig. 7D | Two variables | r and rs | n = 10 mice | r = −0.3601, p = 0.3068rs = −0.3455, p = 0.3304 |
an |
Fig. 7E | Two variables | r and rs | n = 10 mice | r = −0.1352, p = 0.7096rs = 0.006061, p > 0.9999 |
ao |
Fig. 7F | Two variables | r and rs | n = 10 mice | r = 0.3674, p = 0.2963rs = 0.4061, p = 0.2475 |
ap | Fig. 7G | Two variables | r and rs | n = 10 mice | r = 0.05994, p = 0.8694rs = 0.1394, p = 0.7072 |
aq |
Fig. 7H | Two variables | r and rs | n = 10 mice | r = 0.2834, p = 0.4275rs = 0.2485, p = 0.4918 |
ar |
Fig. 8C | Two variables | r and rs | n = 10 mice | r = 0.8011, p = 0.0053rs = 0.8909, p = 0.0011 |
as |
Fig. 8D | Two variables | r and rs | n = 10 mice | r = 0.4686, p = 0.1719rs = 0.5879, p = 0.0806 |