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Research ArticleMethods/New Tools, Disorders of the Nervous System

An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults

Theresa M. Harrison, Zanjbeel Mahmood, Edward P. Lau, Alexandra M. Karacozoff, Alison C. Burggren, Gary W. Small and Susan Y. Bookheimer
eNeuro 27 June 2016, 3 (3) ENEURO.0098-16.2016; https://doi.org/10.1523/ENEURO.0098-16.2016
Theresa M. Harrison
1Neuroscience Interdepartmental Graduate Program, University of California, Los Angeles, Los Angeles, California 90095
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Zanjbeel Mahmood
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Edward P. Lau
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Alexandra M. Karacozoff
3Staglin IMHRO Center for Cognitive Neuroscience, University of California, Los Angeles, Los Angeles, California 90095
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Alison C. Burggren
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
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Gary W. Small
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
4Semel Institute for Neuroscience and Human Behaviors, University of California, Los Angeles, Los Angeles, California 90095
5UCLA Longevity Center, University of California, Los Angeles, Los Angeles, California 90095
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Susan Y. Bookheimer
2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
3Staglin IMHRO Center for Cognitive Neuroscience, University of California, Los Angeles, Los Angeles, California 90095
4Semel Institute for Neuroscience and Human Behaviors, University of California, Los Angeles, Los Angeles, California 90095
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0098-16.2016
PubMed 
27482534
Published By 
Society for Neuroscience
History 
  • Received April 27, 2016
  • Revision received June 8, 2016
  • Accepted June 13, 2016
  • Published online June 27, 2016.
Copyright & Usage 
Copyright © 2016 Harrison et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Theresa M. Harrison1,2,
  2. Zanjbeel Mahmood2,
  3. Edward P. Lau2,
  4. Alexandra M. Karacozoff3,
  5. Alison C. Burggren2,
  6. Gary W. Small2,4,5 and
  7. Susan Y. Bookheimer2,3,4
  1. 1Neuroscience Interdepartmental Graduate Program, University of California, Los Angeles, Los Angeles, California 90095
  2. 2Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095
  3. 3Staglin IMHRO Center for Cognitive Neuroscience, University of California, Los Angeles, Los Angeles, California 90095
  4. 4Semel Institute for Neuroscience and Human Behaviors, University of California, Los Angeles, Los Angeles, California 90095
  5. 5UCLA Longevity Center, University of California, Los Angeles, Los Angeles, California 90095
  1. Correspondence should be addressed to Theresa M. Harrison, Semel Institute for Neuroscience and Human Behavior, The Center for Cognitive Neuroscience, University of California, Los Angeles, 760 Westwood Plaza, B8-169 Los Angeles, CA 90095. E-mail: tessaharrison{at}ucla.edu.
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Author contributions

  1. Author contributions: T.M.H., A.C.B., G.W.S., and S.Y.B. designed research; T.M.H. performed research; T.M.H., Z.M., E.P.L., and A.M.K. analyzed data; T.M.H. wrote the paper.

Disclosures

  • The authors declare no competing financial interests.

  • This work was supported by the National Institute on Aging (Grants 5R01AG013308 to G.W.S. and S.Y.B., and 1F31AG047041 to T.M.H.).

Funding

  • National Institute on Aging

    R01AG013308
  • National Institute on Aging

    F31AG047041

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  • You are viewing the most recent version of this article.
  • previous version (June 27, 2016).

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An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults
Theresa M. Harrison, Zanjbeel Mahmood, Edward P. Lau, Alexandra M. Karacozoff, Alison C. Burggren, Gary W. Small, Susan Y. Bookheimer
eNeuro 27 June 2016, 3 (3) ENEURO.0098-16.2016; DOI: 10.1523/ENEURO.0098-16.2016

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An Alzheimer’s Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults
Theresa M. Harrison, Zanjbeel Mahmood, Edward P. Lau, Alexandra M. Karacozoff, Alison C. Burggren, Gary W. Small, Susan Y. Bookheimer
eNeuro 27 June 2016, 3 (3) ENEURO.0098-16.2016; DOI: 10.1523/ENEURO.0098-16.2016
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Keywords

  • clinical trials
  • normal aging
  • polygenic risk score
  • preclinical Alzheimer's disease
  • structural MRI

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