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Research ArticleNew Research, Sensory and Motor Systems

Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition

Hidehiko Koizumi, Bryan Mosher, Mohammad F. Tariq, Ruli Zhang, Naohiro Koshiya and Jeffrey C. Smith
eNeuro 25 May 2016, 3 (3) ENEURO.0081-16.2016; https://doi.org/10.1523/ENEURO.0081-16.2016
Hidehiko Koizumi
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Bryan Mosher
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Mohammad F. Tariq
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Ruli Zhang
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Naohiro Koshiya
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Jeffrey C. Smith
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0081-16.2016
PubMed 
27275007
Published By 
Society for Neuroscience
History 
  • Received April 17, 2016
  • Accepted May 12, 2016
  • Published online May 25, 2016.
Copyright & Usage 
Copyright © 2016 Koizumi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hidehiko Koizumi,
  2. Bryan Mosher,
  3. Mohammad F. Tariq,
  4. Ruli Zhang,
  5. Naohiro Koshiya and
  6. Jeffrey C. Smith
  1. Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
  1. Correspondence should be addressed to either of the following: Dr. Jeffrey C. Smith, 49 Convent Drive, Room 2A10, NINDS, NIH, Bethesda, MD 20892, E-mail: smithj2{at}helix.nih.gov; or Dr. Hidehiko Koizumi, 49 Convent Drive, Room 2A22, NINDS, NIH, Bethesda, MD 20892, E-mail: koizumih{at}mail.nih.gov.
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Author contributions

  1. ↵2 Author contributions: H.K. and J.C.S. conceived of the study and designed the experiments; H.K., B.M., M.F.T., and R.Z. performed the experiments; H.K., M.F.T., R.Z., and N.K. analyzed the data; H.K., M.F.T., N.K., and J.C.S. wrote the manuscript.

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This research was supported by the Intramural Research Program of National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke. M.F.T. was supported, in part, by the NIH Undergraduate Scholarship Program.

Funding

  • Intramural Research Program of NIH/NINDS

  • NIH Undergraduate Scholarship Program

  • Intramural Research Program of NIH/NINDS

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  • You are viewing the most recent version of this article.
  • previous version (May 25, 2016).

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Jun 201606329
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Jun 2017254
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Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition
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Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition
Hidehiko Koizumi, Bryan Mosher, Mohammad F. Tariq, Ruli Zhang, Naohiro Koshiya, Jeffrey C. Smith
eNeuro 25 May 2016, 3 (3) ENEURO.0081-16.2016; DOI: 10.1523/ENEURO.0081-16.2016

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Voltage-Dependent Rhythmogenic Property of Respiratory Pre-Bötzinger Complex Glutamatergic, Dbx1-Derived, and Somatostatin-Expressing Neuron Populations Revealed by Graded Optogenetic Inhibition
Hidehiko Koizumi, Bryan Mosher, Mohammad F. Tariq, Ruli Zhang, Naohiro Koshiya, Jeffrey C. Smith
eNeuro 25 May 2016, 3 (3) ENEURO.0081-16.2016; DOI: 10.1523/ENEURO.0081-16.2016
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Keywords

  • brainstem microcircuit
  • breathing
  • optogenetics
  • rhythmogenesis

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