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Research ArticleNew Research, Disorders of the Nervous System

TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits

Hongjie Wang, Ruizhi Wang, Ivan Carrera, Shaohua Xu and Madepalli K. Lakshmana
eNeuro 12 May 2016, 3 (3) ENEURO.0042-16.2016; https://doi.org/10.1523/ENEURO.0042-16.2016
Hongjie Wang
1Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987
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Ruizhi Wang
1Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987
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Ivan Carrera
2Department of Neuroscience, Euroespes Biotechnology, 15165A A Coruña, Spain
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Shaohua Xu
3 Florida Institute of Technology, Melbourne, Florida 32901
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Madepalli K. Lakshmana
1Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0042-16.2016
PubMed 
27257626
Published By 
Society for Neuroscience
History 
  • Received February 26, 2016
  • Revision received May 5, 2016
  • Accepted May 6, 2016
  • Published online May 12, 2016.
Copyright & Usage 
Copyright © 2016 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Hongjie Wang1,
  2. Ruizhi Wang1,
  3. Ivan Carrera2,
  4. Shaohua Xu3 and
  5. Madepalli K. Lakshmana1
  1. 1Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987
  2. 2Department of Neuroscience, Euroespes Biotechnology, 15165A A Coruña, Spain
  3. 3 Florida Institute of Technology, Melbourne, Florida 32901
  1. Correspondence should be addressed to Madepalli K. Lakshmana, Section of Neurobiology, Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987. E-mail: mlakshmana{at}tpims.org.
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Author contributions

  1. ↵2 Author contributions: M.K.L. designed research; H.W. and R.W. performed research; I.C. and S.X. contributed unpublished reagents/analytic tools; I.C., S.X., and M.K.L. analyzed data; M.K.L. wrote the paper.

Disclosures

  • ↵1 The authors declare no competing financial interests.

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Jan 20262016315
Feb 20261027529
Mar 20261421675
Apr 20262028859
May 202681820
Total 202672960198
Total750101702865
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TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits
Hongjie Wang, Ruizhi Wang, Ivan Carrera, Shaohua Xu, Madepalli K. Lakshmana
eNeuro 12 May 2016, 3 (3) ENEURO.0042-16.2016; DOI: 10.1523/ENEURO.0042-16.2016

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TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits
Hongjie Wang, Ruizhi Wang, Ivan Carrera, Shaohua Xu, Madepalli K. Lakshmana
eNeuro 12 May 2016, 3 (3) ENEURO.0042-16.2016; DOI: 10.1523/ENEURO.0042-16.2016
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Keywords

  • Alzheimer’s disease
  • autophagy
  • lysosomes
  • PHF-tau
  • Tauopathy
  • TFEB

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