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Research ArticleNew Research, Neuronal Excitability

Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy

David W. Ouedraogo, Pierre-Pascal Lenck-Santini, Geoffrey Marti, David Robbe, Valérie Crépel and Jérôme Epsztein
eNeuro 12 May 2016, 3 (3) ENEURO.0017-16.2016; https://doi.org/10.1523/ENEURO.0017-16.2016
David W. Ouedraogo
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
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Pierre-Pascal Lenck-Santini
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
4Department of Neurological Sciences, University of Vermont, Burlington, Vermont 05405
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Geoffrey Marti
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
5Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Unité Mixte de Recherche 7287, Aix-Marseille University, 13288 Marseille, France
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David Robbe
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
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Valérie Crépel
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
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Jérôme Epsztein
1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0017-16.2016
PubMed 
27257629
Published By 
Society for Neuroscience
History 
  • Received January 26, 2016
  • Revision received April 26, 2016
  • Accepted April 28, 2016
  • Published online May 12, 2016.
Copyright & Usage 
Copyright © 2016 Ouedraogo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. David W. Ouedraogo1,2,3,
  2. Pierre-Pascal Lenck-Santini1,2,3,4,
  3. Geoffrey Marti1,2,3,5,
  4. David Robbe1,2,3,
  5. Valérie Crépel1,2,3 and
  6. Jérôme Epsztein1,2,3
  1. 1Institut National de la Santé et de la Recherche Médicale U901, 13273 Marseille, France
  2. 2Unité Mixte de Recherche 901, Aix-Marseille University, 13273 Marseille, France
  3. 3Institut de neurobiologie de la méditerranée, 13273 Marseille, France
  4. 4Department of Neurological Sciences, University of Vermont, Burlington, Vermont 05405
  5. 5Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Unité Mixte de Recherche 7287, Aix-Marseille University, 13288 Marseille, France
  1. Correspondence should be addressed to Dr. Jérôme Epsztein, INMED/INSERM U901, Parc scientifique de Luminy, 163 route de Luminy, BP 13, 13273 Marseille cedex 09. E-mail: jerome.epsztein{at}inserm.fr.
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Author contributions

  1. ↵2 Author contributions: D.W.O., V.C., and J.E. designed research; D.W.O. performed research; P.-P.L.-S., G.M., and D.R. contributed unpublished reagents/analytic tools; D.W.O., and J.E. analyzed data; D.W.O., V.C., and J.E. wrote the paper.

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This research was supported by Institut National de la Santé et de la Recherche Médicale, Aix-Marseille University, Agence Nationale de la Recherche (Epileptic-Code, ANR-09-BLAN-0259–01; KAREP, ANR-2010-BLAN-1406-01 to V.C.); Ministère de l’Enseignement Supérieur et de la Recherche (to D.W.O.); Service de coopération de l'ambassade de France à Ouagadougou (to D.W.O.); and National Institutes of Health Grant R01-NS-076763 (to P.-P.L.-S.).

Funding

  • INSERM

  • Agence national de la sante et de la recherche medicale

    Epileptic-Code; ANR-09-BLAN-025901; KAREP; ANR-2010-BLAN-1406-01
  • Ministere de l'education nationale et de la recherche

    Allocation de recherche
  • NIH

    R01 NS076763
  • Aix-Marseille University

  • Service de la cooperation de l'ambassade de France a Ouagadougou

    Bourse d'etude

Other Version

  • You are viewing the most recent version of this article.
  • previous version (May 12, 2016).

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AbstractFullPdf
Jun 201605264
Jul 201602624
Aug 201602618
Sep 201601810
Oct 201602520
Nov 20160226
Dec 20160146
Total 20160183148
Jan 20170217
Feb 20170128
Mar 20170126
Apr 2017887
May 2017102018
Jun 2017166
Jul 2017111212
Aug 201742223
Sep 2017164139
Oct 2017226051
Nov 20172621726
Dec 201746120916
Total 20171441640219
Jan 201839100527
Feb 20182010916
Mar 201894322
Apr 2018114211
May 2018138018
Jun 2018235417
Jul 201813436
Aug 201893513
Sep 201834210
Oct 2018203310
Nov 2018363410
Dec 20188314
Total 20182041551164
Jan 201911369
Feb 20197374
Mar 201945115
Apr 2019114221
May 201916024
Jun 2019212327
Jul 2019112321
Aug 2019714620
Oct 201934519
Nov 201943925
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Total 201956729198
Jan 20204265
Feb 202023018
Mar 20205414
May 202042913
Jun 20202248
Jul 202032613
Aug 20203229
Sep 20206384
Oct 20207706
Nov 20205548
Dec 20205554
Total 20204641592
Jan 20214478
Feb 20211459
Mar 2021116511
Apr 20212532
May 202110566
Jun 20219477
Jul 202195410
Aug 20215489
Sep 20214573
Oct 20211634
Nov 20215519
Dec 20215496
Total 20216663584
Jan 20227536
Feb 20228367
Mar 20224342
Apr 20225386
May 20224596
Jun 20224455
Jul 20223387
Aug 202232385
Sep 202217455
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Total 202210750581
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Feb 20233429
Mar 20231391
Apr 202304810
May 202315111
Jun 20231445
Jul 202324918
Aug 202314119
Sep 20230446
Oct 20231486
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Total 202320550113
Jan 20244574
Feb 20244446
Mar 202434413
Apr 20247509
May 20242454
Jun 202445418
Jul 202425310
Aug 202465918
Sep 20245577
Oct 20240464
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Total 202441599106
Jan 202525212
Feb 202517214
Mar 202545912
Apr 202536311
May 20250486
Jun 202557110
Jul 20251169
Total 20251638174
Total70071881279
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Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy
David W. Ouedraogo, Pierre-Pascal Lenck-Santini, Geoffrey Marti, David Robbe, Valérie Crépel, Jérôme Epsztein
eNeuro 12 May 2016, 3 (3) ENEURO.0017-16.2016; DOI: 10.1523/ENEURO.0017-16.2016

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Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy
David W. Ouedraogo, Pierre-Pascal Lenck-Santini, Geoffrey Marti, David Robbe, Valérie Crépel, Jérôme Epsztein
eNeuro 12 May 2016, 3 (3) ENEURO.0017-16.2016; DOI: 10.1523/ENEURO.0017-16.2016
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Keywords

  • dentate gyrus
  • epilepsy
  • in vivo whole-cell recordings
  • sleep
  • slow oscillation
  • UP/DOWN state

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