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Research ArticleNew Research, Neuronal Excitability

Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity

Go Kato, Hiroyuki Inada, Hiroaki Wake, Ryohei Akiyoshi, Akiko Miyamoto, Kei Eto, Tatsuya Ishikawa, Andrew J. Moorhouse, Andrew M. Strassman and Junichi Nabekura
eNeuro 3 June 2016, 3 (3) ENEURO.0004-16.2016; https://doi.org/10.1523/ENEURO.0004-16.2016
Go Kato
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
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Hiroyuki Inada
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
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  • ORCID record for Hiroyuki Inada
Hiroaki Wake
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
6Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Saitama, Japan
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Ryohei Akiyoshi
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
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Akiko Miyamoto
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
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Kei Eto
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
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Tatsuya Ishikawa
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
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Andrew J. Moorhouse
2Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney 2052, New South Wales, Australia
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Andrew M. Strassman
4Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
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Junichi Nabekura
1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
5Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development (AMED), Tokyo, Japan
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0004-16.2016
PubMed 
27390772
Published By 
Society for Neuroscience
History 
  • Received January 5, 2016
  • Revision received April 29, 2016
  • Accepted May 18, 2016
  • Published online June 3, 2016.
Copyright & Usage 
Copyright © 2016 Kato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Go Kato1,3,
  2. Hiroyuki Inada1,3,
  3. Hiroaki Wake1,3,6,
  4. Ryohei Akiyoshi1,3,
  5. Akiko Miyamoto1,
  6. Kei Eto1,3,
  7. Tatsuya Ishikawa1,3,
  8. Andrew J. Moorhouse2,
  9. Andrew M. Strassman4 and
  10. Junichi Nabekura1,3,5
  1. 1Divison of Homeostatic Development, National Institute for Physiological Sciences, Okazaki 444-8585, Japan
  2. 2Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney 2052, New South Wales, Australia
  3. 3Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Nishigo-naka, Myodaiji-cho, Japan
  4. 4Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
  5. 5Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development (AMED), Tokyo, Japan
  6. 6Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Saitama, Japan
  1. Correspondence should be addressed to Dr. Junichi Nabekura, Division of Homeostatic Development, National Institute for Physiological Sciences, Nishigo-naka, Myodaiji-cho, Okazaki 444-8585, Japan. E-mail: nabekura{at}nips.ac.jp.
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Author contributions

  1. ↵2 Author contributions: G.K., A.M.S., and J.N. designed research; G.K. performed research; G.K., H.I., H.W., R.A., A.M., K.E., T.I., and A.J.M. analyzed data; G.K., H.I., H.W., R.A., A.M., K.E., T.I., and A.J.M. wrote the paper.

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work was supported by Japan Agency for Medical Research and Development (AMED) for Core Research for Evolutional Science and Technology (CREST) (to J.N.).

Funding

  • Japan Science and Technology Agency for Core Research for Evolutional Science and Technology

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Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity
Go Kato, Hiroyuki Inada, Hiroaki Wake, Ryohei Akiyoshi, Akiko Miyamoto, Kei Eto, Tatsuya Ishikawa, Andrew J. Moorhouse, Andrew M. Strassman, Junichi Nabekura
eNeuro 3 June 2016, 3 (3) ENEURO.0004-16.2016; DOI: 10.1523/ENEURO.0004-16.2016

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Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity
Go Kato, Hiroyuki Inada, Hiroaki Wake, Ryohei Akiyoshi, Akiko Miyamoto, Kei Eto, Tatsuya Ishikawa, Andrew J. Moorhouse, Andrew M. Strassman, Junichi Nabekura
eNeuro 3 June 2016, 3 (3) ENEURO.0004-16.2016; DOI: 10.1523/ENEURO.0004-16.2016
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Keywords

  • microglia
  • excitotoxicty
  • axonal swelling
  • atp release
  • neuronal rescue

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