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Research ArticleNew Research, Disorders of the Nervous System

Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex

Tahra L. Eissa, Andrew K. Tryba, Charles J. Marcuccilli, Faiza Ben-Mabrouk, Elliot H. Smith, Sean M. Lew, Robert R. Goodman, Guy M. McKhann Jr, David M. Frim, Lorenzo L. Pesce, Michael H. Kohrman, Ronald G. Emerson, Catherine A. Schevon and Wim van Drongelen
eNeuro 26 April 2016, 3 (2) ENEURO.0141-15.2016; https://doi.org/10.1523/ENEURO.0141-15.2016
Tahra L. Eissa
1Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
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Andrew K. Tryba
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
3Department Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
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Charles J. Marcuccilli
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
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Faiza Ben-Mabrouk
3Department Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
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Elliot H. Smith
4Department of Neurological Surgery, Columbia University, New York, New York 10032
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Sean M. Lew
5Department Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
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Robert R. Goodman
6Department of Neurosurgery, Mount Sinai Hospital, New York, New York 10029
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Guy M. McKhann Jr
4Department of Neurological Surgery, Columbia University, New York, New York 10032
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David M. Frim
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
7Department Surgery, The University of Chicago, Chicago, Illinois 60637
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Lorenzo L. Pesce
8The Computation Institute, The University of Chicago, Chicago, Illinois 60637
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Michael H. Kohrman
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
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Ronald G. Emerson
4Department of Neurological Surgery, Columbia University, New York, New York 10032
9Department of Neurology, Columbia University, New York, New York 10032
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Catherine A. Schevon
9Department of Neurology, Columbia University, New York, New York 10032
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Wim van Drongelen
1Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637
2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
8The Computation Institute, The University of Chicago, Chicago, Illinois 60637
10Committee on Computational Neuroscience, The University of Chicago, Chicago, Illinois 60637
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0141-15.2016
PubMed 
27257623
Published By 
Society for Neuroscience
History 
  • Received November 20, 2015
  • Revision received April 19, 2016
  • Accepted April 21, 2016
  • Published online April 26, 2016.
Copyright & Usage 
Copyright © 2016 Eissa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tahra L. Eissa1,2,
  2. Andrew K. Tryba2,3,
  3. Charles J. Marcuccilli2,
  4. Faiza Ben-Mabrouk3,
  5. Elliot H. Smith4,
  6. Sean M. Lew5,
  7. Robert R. Goodman6,
  8. Guy M. McKhann Jr4,
  9. David M. Frim2,7,
  10. Lorenzo L. Pesce8,
  11. Michael H. Kohrman2,
  12. Ronald G. Emerson4,9,
  13. Catherine A. Schevon9 and
  14. Wim van Drongelen1,2,8,10
  1. 1Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637
  2. 2Departments of Pediatrics, The University of Chicago, Chicago, Illinois 60637
  3. 3Department Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
  4. 4Department of Neurological Surgery, Columbia University, New York, New York 10032
  5. 5Department Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
  6. 6Department of Neurosurgery, Mount Sinai Hospital, New York, New York 10029
  7. 7Department Surgery, The University of Chicago, Chicago, Illinois 60637
  8. 8The Computation Institute, The University of Chicago, Chicago, Illinois 60637
  9. 9Department of Neurology, Columbia University, New York, New York 10032
  10. 10Committee on Computational Neuroscience, The University of Chicago, Chicago, Illinois 60637
  1. Correspondence should be addressed to Tahra L. Eissa, University of Chicago, 900 E. 57th Street, 4121c Knapp Center for Biomedical Discovery, Chicago, IL 60637-1428. E-mail: teissa{at}uchicago.edu.
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Author contributions

  1. ↵2 Author Contributions: T.L.E. and W.v.D. designed research; T.L.E., L.L.P., and W.v.D. contributed unpublished reagents/analytic tools; T.L.E. analyzed data; T.L.E., A.K.T., C.J.M., F.B.-M., E.H.S., S.M.L., R.R.G., G.M.M., D.M.F., L.L.P., M.H.K., R.G.E., C.A.S., and W.v.D. wrote the paper; A.K.T., C.J.M., F.B.-M., E.H.S., S.M.L., R.R.G., G.M.M., D.M.F., M.H.K., R.G.E., and C.A.S. performed research.

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work is funded by National Institutes of Health Grants 1R01-NS-084142 and R01-NS-095368, and the Dr. Ralph and Marian Falk Medical Research Trust.

Funding

  • NINDS

    1R01 NS084142
  • NINDS

    R01 NS095368-01
  • Dr. Ralph and Marian Falk Medical Research Trust

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 26, 2016).

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Jun 20160258
Jul 20160126
Aug 20160207
Sep 20160149
Oct 201602010
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Total 2016012653
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Apr 2017131615
May 201761311
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Jul 2017377
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Jan 2018146645
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Apr 201893911
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Sep 20181706
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Apr 20195318
May 20197225
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Jul 201933123
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Oct 20195289
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Total 201950624116
Jan 20202229
Feb 202012118
Mar 20201163
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Total 202025354110
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Total 202133650123
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Apr 202474612
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Jun 20242538
Jul 202414311
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Total 202443549123
Jan 202524917
Feb 20250639
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Apr 202524316
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Total 2025529264
Total41664281146
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Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex
Tahra L. Eissa, Andrew K. Tryba, Charles J. Marcuccilli, Faiza Ben-Mabrouk, Elliot H. Smith, Sean M. Lew, Robert R. Goodman, Guy M. McKhann Jr, David M. Frim, Lorenzo L. Pesce, Michael H. Kohrman, Ronald G. Emerson, Catherine A. Schevon, Wim van Drongelen
eNeuro 26 April 2016, 3 (2) ENEURO.0141-15.2016; DOI: 10.1523/ENEURO.0141-15.2016

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Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex
Tahra L. Eissa, Andrew K. Tryba, Charles J. Marcuccilli, Faiza Ben-Mabrouk, Elliot H. Smith, Sean M. Lew, Robert R. Goodman, Guy M. McKhann Jr, David M. Frim, Lorenzo L. Pesce, Michael H. Kohrman, Ronald G. Emerson, Catherine A. Schevon, Wim van Drongelen
eNeuro 26 April 2016, 3 (2) ENEURO.0141-15.2016; DOI: 10.1523/ENEURO.0141-15.2016
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Keywords

  • epilepsy
  • HFOs
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  • neocortex
  • seizure

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