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Research ArticleNew Research, Disorders of the Nervous System

Functional Mechanisms of Recovery after Chronic Stroke: Modeling with the Virtual Brain

Maria Inez Falcon, Jeffrey D. Riley, Viktor Jirsa, Anthony R. McIntosh, E. Elinor Chen and Ana Solodkin
eNeuro 23 March 2016, 3 (2) ENEURO.0158-15.2016; DOI: https://doi.org/10.1523/ENEURO.0158-15.2016
Maria Inez Falcon
1Department of Anatomy and Neurobiology, UC Irvine School of Medicine, Irvine, California 92697
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Jeffrey D. Riley
1Department of Anatomy and Neurobiology, UC Irvine School of Medicine, Irvine, California 92697
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Viktor Jirsa
2Institut de Neurosciences des Systèmes, Aix-Marseille Université, Faculté de Médecine, Marseille F-13000, France
3Inserm UMR1106, Marseille F-13000, France
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Anthony R. McIntosh
4Rotman Research Institute, Baycrest Health Sciences, M6A 2E1 University of Toronto, Toronto, Canada
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E. Elinor Chen
1Department of Anatomy and Neurobiology, UC Irvine School of Medicine, Irvine, California 92697
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Ana Solodkin
1Department of Anatomy and Neurobiology, UC Irvine School of Medicine, Irvine, California 92697
5Department of Neurology, UC Irvine School of Medicine, Irvine, California 92697
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0158-15.2016
PubMed 
27088127
Published By 
Society for Neuroscience
History 
  • Received December 17, 2015
  • Revision received January 25, 2016
  • Accepted March 15, 2016
  • Published online March 23, 2016.
Copyright & Usage 
Copyright © 2016 Falcon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Maria Inez Falcon1,
  2. Jeffrey D. Riley1,
  3. Viktor Jirsa2,3,
  4. Anthony R. McIntosh4,
  5. E. Elinor Chen1 and
  6. Ana Solodkin1,5
  1. 1Department of Anatomy and Neurobiology, UC Irvine School of Medicine, Irvine, California 92697
  2. 2Institut de Neurosciences des Systèmes, Aix-Marseille Université, Faculté de Médecine, Marseille F-13000, France
  3. 3Inserm UMR1106, Marseille F-13000, France
  4. 4Rotman Research Institute, Baycrest Health Sciences, M6A 2E1 University of Toronto, Toronto, Canada
  5. 5Department of Neurology, UC Irvine School of Medicine, Irvine, California 92697
  1. Correspondence should be addressed to Dr Ana Solodkin, Anatomy and Neurobiology; Neurology, Hewitt Hall, Room 1505, UC Irvine Medical School, Irvine, CA 92697. E-mail: Solodkin{at}uci.edu.
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Author contributions

  1. ↵2 Author contributions: All authors had full access to all data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. A.S., V.J., and M.I.F. designed research; A.S., J.D.R., and M.I.F. performed research; A.S., M.I.F., J.D.R., V.J., E.E.C., and A.R.M. analyzed data; M.I.F., A.S., V.J., J.D.R., and A.R.M. wrote the paper.

Disclosures

  • ↵1 The authors report no conflict of interest.

  • ↵3 This work was supported by the James McDonnell Foundation (NRG Group), the National Institutes of Health (NIH RO1-NS-54942), and the European Union Seventh Framework Programme (FP7-ICT BrainScales and Human Brain Project, grant 60402). We thank Dr Ahmeed Shereen for the generation of the structural connectomes.

Funding

  • James McDonnell Foundation

  • National Institutes of Health

    NIH RO1-NS-54942
  • European Union Seventh Framework Programme (FP7-ICT BrainScales and Human Brain Project)

    60402

Other Version

  • previous version (March 23, 2016).
  • You are viewing the most recent version of this article.

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Mar 2016110038
Apr 2016104441353
May 20163011754
Jun 20161414456
Jul 20161015463
Aug 20161810063
Sep 2016136939
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Total 20163621377821
Jan 20172610572
Feb 2017207743
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Apr 2017376846
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Jun 2017298240
Jul 2017185159
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Sep 2017228955
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Total 20173751076633
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Jul 2018332634
Aug 2018295642
Sep 2018118218
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Total 20183071250382
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Feb 20191316715
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Apr 2019716916
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Aug 20191247317
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Total 20191313323323
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Jul 20201610019
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Total 2020132927260
Jan 202186018
Feb 20215619
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Jul 202156118
Aug 202144919
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Total 202169771254
Jan 202257134
Feb 202227517
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Apr 202228126
May 202236812
Total 202216376125
Total139291002798
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Functional Mechanisms of Recovery after Chronic Stroke: Modeling with the Virtual Brain
Maria Inez Falcon, Jeffrey D. Riley, Viktor Jirsa, Anthony R. McIntosh, E. Elinor Chen, Ana Solodkin
eNeuro 23 March 2016, 3 (2) ENEURO.0158-15.2016; DOI: 10.1523/ENEURO.0158-15.2016

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Functional Mechanisms of Recovery after Chronic Stroke: Modeling with the Virtual Brain
Maria Inez Falcon, Jeffrey D. Riley, Viktor Jirsa, Anthony R. McIntosh, E. Elinor Chen, Ana Solodkin
eNeuro 23 March 2016, 3 (2) ENEURO.0158-15.2016; DOI: 10.1523/ENEURO.0158-15.2016
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Keywords

  • brain dynamics
  • brain networks
  • computational biophysical modeling
  • connectome
  • imaging
  • stroke

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