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Research ArticleNew Research, Disorders of the Nervous System

Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia

Sinéad Kinsella, Hans-Georg König and Jochen H.M. Prehn
eNeuro 2 May 2016, 3 (2) ENEURO.0099-15.2016; DOI: https://doi.org/10.1523/ENEURO.0099-15.2016
Sinéad Kinsella
Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
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Hans-Georg König
Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
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Jochen H.M. Prehn
Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0099-15.2016
PubMed 
27257617
Published By 
Society for Neuroscience
History 
  • Received August 28, 2015
  • Revision received April 7, 2016
  • Accepted April 11, 2016
  • Published online May 2, 2016.
Copyright & Usage 
Copyright © 2016 Kinsella et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Sinéad Kinsella,
  2. Hans-Georg König and
  3. Jochen H.M. Prehn
  1. Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland
  1. Correspondence should be addressed to Jochen H. M. Prehn, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland. E-mail: prehn{at}rcsi.ie.
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Author contributions

  1. ↵2 Author contributions: S.K., H.-G.K., and J.H.M.P. designed research; S.K. performed research; S.K. and H.-G.K. analyzed data; S.K., H.-G.K., and J.H.M.P. wrote the paper.

Disclosures

  • ↵1 The authors declare no conflict of interest.

  • ↵3 This work was supported by the BioAnalysis and Therapeutics PhD scholars program under the Programme for Research in Third Level Institutions (PRTLI) Cycle 5 and funding from the Science Foundation Ireland (08/INV.1/B1949). The PRTLI is co-funded through the European Regional Development Fund, part of the European Union Structural Funds Programme 2007–2013. We thank Mathew King for the generation of the plasmids encoding the SOD1G93A-CFP fusion protein, Ina Woods and Shona Pfeiffer for proficient technical assistance in animal breeding, Caroline Jefferies for some valuable advice and for donating the Ubiquitin encoding plasmid, and Manuela Salvucci for assistance with statistical analyses.

Funding

  • This work is funded by the BioAnalysis and Therapeutics PhD scholars programme unde the Programme for Research in Third Level Institutes (PRTLI) Cycle 5. The PRTLI is funded under the European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme 2007 - 2013.

    PRTLI Cycle 5
  • Science Foundation Ireland (SFI)

    501100001602; 08/INV.1/B1949

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Jun 201605136
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Apr 20231399
May 202304015
Jun 20230384
Jul 202324121
Aug 202343820
Sep 20231292
Total 2023934694
Total51468961058
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Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia
Sinéad Kinsella, Hans-Georg König, Jochen H.M. Prehn
eNeuro 2 May 2016, 3 (2) ENEURO.0099-15.2016; DOI: 10.1523/ENEURO.0099-15.2016

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Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia
Sinéad Kinsella, Hans-Georg König, Jochen H.M. Prehn
eNeuro 2 May 2016, 3 (2) ENEURO.0099-15.2016; DOI: 10.1523/ENEURO.0099-15.2016
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Keywords

  • microglia
  • NF-κB
  • SOD1G93A protein
  • TLR
  • Toll-like Receptor 4

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