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Research ArticleNew Research, Disorders of the Nervous System

c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea

Tommi Anttonen, Anni Herranen, Jussi Virkkala, Anna Kirjavainen, Pinja Elomaa, Maarja Laos, Xingqun Liang, Jukka Ylikoski, Axel Behrens and Ulla Pirvola
eNeuro 24 April 2016, 3 (2) ENEURO.0047-16.2016; https://doi.org/10.1523/ENEURO.0047-16.2016
Tommi Anttonen
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Anni Herranen
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Jussi Virkkala
2 Finnish Institute of Occupational Health, 00251 Helsinki, Finland
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Anna Kirjavainen
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Pinja Elomaa
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Maarja Laos
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Xingqun Liang
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Jukka Ylikoski
3 Helsinki Ear Institute, 00420 Helsinki, Finland
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Axel Behrens
4 The Francis Crick Institute and King's College London, London SE1 1UL, UK
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Ulla Pirvola
1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0047-16.2016
PubMed 
27257624
Published By 
Society for Neuroscience
History 
  • Received March 4, 2016
  • Revision received April 13, 2016
  • Accepted April 18, 2016
  • Published online April 24, 2016.
Copyright & Usage 
Copyright © 2016 Anttonen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Tommi Anttonen1,*,
  2. Anni Herranen1,*,
  3. Jussi Virkkala2,
  4. Anna Kirjavainen1,
  5. Pinja Elomaa1,
  6. Maarja Laos1,
  7. Xingqun Liang1,
  8. Jukka Ylikoski3,
  9. Axel Behrens4 and
  10. Ulla Pirvola1
  1. 1Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland
  2. 2 Finnish Institute of Occupational Health, 00251 Helsinki, Finland
  3. 3 Helsinki Ear Institute, 00420 Helsinki, Finland
  4. 4 The Francis Crick Institute and King's College London, London SE1 1UL, UK
  1. Correspondence should be addressed to Ulla Pirvola, Department of Biosciences, P.O. Box 65, Viikinkaari 1, University of Helsinki, 00014 Helsinki, Finland. E-mail: ulla.pirvola{at}helsinki.fi.
  • X. Liang’s present address: Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China.

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Author contributions

  1. ↵2 Author contributions: T.A., A.H., and U.P. designed research; T.A., A.H., J.V., A.K., P.E., M.L., X.L., J.Y., and U.P. performed research; T.A., A.H., J.V., X.L., J.Y., and U.P. analyzed data; A.B. provided materials; T.A., A.H., and U.P. wrote the article. All authors reviewed the article. J.Y. and A.B. contributed unpublished reagents/analytic tools.

  2. ↵* T.A. and A.H. contributed equally to this work.

  • X. Liang’s present address: Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China.

Disclosures

  • ↵1 The authors declare no conflicting financial interests.

  • ↵3 This work was supported by the Jane and Aatos Erkko Foundation, the Päivikki and Sakari Sohlberg Foundation, the Instrumentarium Foundation, the Paulo Foundation, The Finnish Work Environment Fund (project # 115145), and The Finnish Society of Sciences and Letters.

Funding

  • Jane ja Aatos Erkko Foundation

  • Päivikki ja Sakari Sohlberg Foundation

  • Instrumentarium Foundation

  • The Finnish Society of Science and Letters

  • Paulo Foundation

Other Version

  • You are viewing the most recent version of this article.
  • previous version (April 24, 2016).

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Jun 201604728
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Oct 20160238
Nov 20160147
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Jan 201703320
Feb 201702917
Mar 201701710
Apr 201761214
May 201762223
Jun 2017122148
Jul 2017123042
Aug 201753751
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Apr 2018193743
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Jun 2018185758
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Sep 201845213
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Total 2018128839355
Jan 2019414930
Feb 2019516316
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Apr 201937612
May 201922717
Jun 201923826
Jul 201934416
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Total 201945732235
Jan 20206429
Feb 202031616
Mar 20205166
May 20202186
Jun 20202236
Jul 20204245
Aug 202002121
Sep 202010476
Oct 202056911
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Feb 20214456
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Apr 20213461
May 20217538
Jun 202104418
Jul 202116118
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Sep 20211517
Oct 202106321
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Total 202133613154
Jan 202206121
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Apr 20220389
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Jan 20245454
Feb 20244517
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Apr 202499534
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Jun 202435212
Jul 202404617
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Mar 202537227
Apr 20251538
May 202546514
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Jul 202537118
Aug 2025510413
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Total 202556953197
Jan 2026713818
Feb 202621037
Total 2026924125
Total54260222062
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c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea
Tommi Anttonen, Anni Herranen, Jussi Virkkala, Anna Kirjavainen, Pinja Elomaa, Maarja Laos, Xingqun Liang, Jukka Ylikoski, Axel Behrens, Ulla Pirvola
eNeuro 24 April 2016, 3 (2) ENEURO.0047-16.2016; DOI: 10.1523/ENEURO.0047-16.2016

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c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea
Tommi Anttonen, Anni Herranen, Jussi Virkkala, Anna Kirjavainen, Pinja Elomaa, Maarja Laos, Xingqun Liang, Jukka Ylikoski, Axel Behrens, Ulla Pirvola
eNeuro 24 April 2016, 3 (2) ENEURO.0047-16.2016; DOI: 10.1523/ENEURO.0047-16.2016
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Keywords

  • c-Jun phosphorylation
  • cell death
  • hair cell
  • inner ear
  • noise
  • supporting cell

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