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Research ArticleNew Research, Development

Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction

Haneui Bae, Shirui Chen, John P. Roche, Minrong Ai, Chunlai Wu, Aaron Diantonio and Ethan R. Graf
eNeuro 7 March 2016, 3 (2) ENEURO.0031-16.2016; https://doi.org/10.1523/ENEURO.0031-16.2016
Haneui Bae
1Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
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Shirui Chen
1Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
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John P. Roche
1Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
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Minrong Ai
2Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110
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Chunlai Wu
3Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
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Aaron Diantonio
2Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110
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Ethan R. Graf
1Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0031-16.2016
PubMed 
27022630
Published By 
Society for Neuroscience
History 
  • Received February 15, 2016
  • Accepted February 29, 2016
  • Published online March 7, 2016.
Copyright & Usage 
Copyright © 2016 Bae et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Haneui Bae1,
  2. Shirui Chen1,
  3. John P. Roche1,
  4. Minrong Ai2,
  5. Chunlai Wu3,
  6. Aaron Diantonio2 and
  7. Ethan R. Graf1
  1. 1Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
  2. 2Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110
  3. 3Department of Cell Biology and Anatomy, Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
  1. Correspondence should be addressed to Dr Ethan R. Graf, Department of Biology, Campus Box 2237, Amherst College, Amherst, MA 01002. E-mail: egraf{at}amherst.edu.
  • M. Ai’s present address: Eli Lilly & Companies, Division of Endocrine, Indianapolis, IN 46225.

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Author contributions

  1. ↵2 Author contributions: H.B., J.P.R., M.A., A.D., and E.R.G. designed research; H.B., J.P.R., M.A., and E.R.G. performed research; S.C., M.A., and C.W. contributed unpublished reagents/analytic tools; H.B., J.P.R., M.A., and E.R.G. analyzed data; E.R.G. and A.D. wrote the paper.

  • M. Ai’s present address: Eli Lilly & Companies, Division of Endocrine, Indianapolis, IN 46225.

Disclosures

  • ↵1 The authors report no conflict of interest.

  • ↵3 This work was supported by the National Institutes of Health Grants NS087601 (E.R.G.) and DA020812 (A.D.). We thank members of the Graf and DiAntonio laboratories for helpful discussions; Maureen Manning, Lori Nichols, Sylvia Johnson, and Xiaolu Sun for technical assistance; Josef Trapani for experimental assistance; and the Bloomington stock center and the Developmental Studies Hybridoma Bank for fly strains and antibodies.

Funding

  • NIH National Institute of Neurological Disorders and Stroke (NINDS)

    NS087601
  • NIH National Institute on Drug Abuse (NIDA)

    DA020812

Other Version

  • You are viewing the most recent version of this article.
  • previous version (March 07, 2016).

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Total64897521789
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Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction
Haneui Bae, Shirui Chen, John P. Roche, Minrong Ai, Chunlai Wu, Aaron Diantonio, Ethan R. Graf
eNeuro 7 March 2016, 3 (2) ENEURO.0031-16.2016; DOI: 10.1523/ENEURO.0031-16.2016

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Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction
Haneui Bae, Shirui Chen, John P. Roche, Minrong Ai, Chunlai Wu, Aaron Diantonio, Ethan R. Graf
eNeuro 7 March 2016, 3 (2) ENEURO.0031-16.2016; DOI: 10.1523/ENEURO.0031-16.2016
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Keywords

  • Active Zone
  • Drosophila
  • neuromuscular junction
  • Rab3
  • synapse

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