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Research ArticleNew Research, Disorders of the Nervous System

Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome

Maneesh G. Kumar, Shane Rowley, Ruth Fulton, Matthew T. Dinday, Scott C. Baraban and Manisha Patel
eNeuro 29 March 2016, 3 (2) ENEURO.0008-16.2016; https://doi.org/10.1523/ENEURO.0008-16.2016
Maneesh G. Kumar
1Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
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Shane Rowley
1Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
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Ruth Fulton
1Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
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Matthew T. Dinday
2Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143
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Scott C. Baraban
2Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143
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Manisha Patel
1Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0008-16.2016
PubMed 
27066534
Published By 
Society for Neuroscience
History 
  • Received January 12, 2016
  • Revision received March 23, 2016
  • Accepted March 24, 2016
  • Published online March 29, 2016.
Copyright & Usage 
Copyright © 2016 Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Maneesh G. Kumar1,
  2. Shane Rowley1,
  3. Ruth Fulton1,
  4. Matthew T. Dinday2,
  5. Scott C. Baraban2 and
  6. Manisha Patel1
  1. 1Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045
  2. 2Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143
  1. Correspondence should be addressed to Dr Manisha Patel, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Mail Stop C238 V20-3119, 12850 East Montview Boulevard, Aurora, CO 80045. E-mail: manisha.patel{at}ucdenver.edu.
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Author contributions

  1. ↵2 Author contributions: M.G.K., S.C.B., and M.P. designed research; M.G.K. performed research; M.G.K. analyzed data; S.R., R.F., M.T.D., and S.C.B. contributed unpublished reagents/analytic tools; M.G.K., S.C.B., and M.P. wrote the paper.

Disclosures

  • ↵1 The authors report no conflict of interest.

  • ↵3 This work was supported by the NIH R01NS39587(M.P.), NIH R01NS079214 (S.C.B.), and (in part) by a sabbatical grant from the Associate Dean of Research Seed Grant Program, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado. We thank the zebrafish transgenic core at the University of Colorado (P30NS048154), in particular Dr Kristin Artinger, Ana-Laura Hernandez, Morgan Singleton, and Michelle Tellez.

Funding

  • DH | National Institute for Health Research (NIHR)

    501100000272; R01NS39587(MP)
  • DH | National Institute for Health Research (NIHR)

    501100000272; R01NS079214(SCB)

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  • You are viewing the most recent version of this article.
  • previous version (March 29, 2016).

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eneuro: 3 (2)
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March/April 2016
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Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome
Maneesh G. Kumar, Shane Rowley, Ruth Fulton, Matthew T. Dinday, Scott C. Baraban, Manisha Patel
eNeuro 29 March 2016, 3 (2) ENEURO.0008-16.2016; DOI: 10.1523/ENEURO.0008-16.2016

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Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome
Maneesh G. Kumar, Shane Rowley, Ruth Fulton, Matthew T. Dinday, Scott C. Baraban, Manisha Patel
eNeuro 29 March 2016, 3 (2) ENEURO.0008-16.2016; DOI: 10.1523/ENEURO.0008-16.2016
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Keywords

  • Dravet syndrome
  • epilepsy
  • glycolysis
  • metabolism
  • Mitochondrial Respiration
  • zebrafish

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