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Research ArticleNew Research, Sensory and Motor Systems

Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain

Ihab Daou, Hélène Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil and Philippe Séguéla
eNeuro 25 February 2016, 3 (1) ENEURO.0140-15.2016; DOI: https://doi.org/10.1523/ENEURO.0140-15.2016
Ihab Daou
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
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Hélène Beaudry
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
3Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
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Ariel R. Ase
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
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Jeffrey S. Wieskopf
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
4Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
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Alfredo Ribeiro-da-Silva
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
3Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
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Jeffrey S. Mogil
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
4Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
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Philippe Séguéla
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0140-15.2016
PubMed 
27022626
Published By 
Society for Neuroscience
History 
  • Received November 18, 2015
  • Revision received February 3, 2016
  • Accepted February 19, 2016
  • Published online February 25, 2016.
Copyright & Usage 
Copyright © 2016 Daou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ihab Daou1,2,
  2. Hélène Beaudry1,2,3,
  3. Ariel R. Ase1,2,
  4. Jeffrey S. Wieskopf2,4,
  5. Alfredo Ribeiro-da-Silva2,3,
  6. Jeffrey S. Mogil2,4 and
  7. Philippe Séguéla1,2
  1. 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
  2. 2The Alan Edwards Centre for Research on Pain, Montreal, Quebec H3A 0G1, Canada
  3. 3Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
  4. 4Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
  1. Correspondence should be addressed to Philippe Séguéla, Montreal Neurological Institute, 3801 University, Suite 778, Montreal, QC H3A 2B4, Canada. E-mail: philippe.seguela{at}mcgill.ca.
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Author contributions

  1. ↵2 Author contributions: I.D. and P.S. designed research; I.D., H.B., A.R.A., and J.S.W. performed research; I.D., H.B., A.R.A., J.S.W., A.R.-d.-S., J.S.M., and P.S. analyzed data; I.D. and P.S. wrote the paper; A.R.-d.-S. and J.S.M. contributed unpublished reagents/analytic tools.

Disclosures

  • ↵1 The authors declare no competing financial interests.

  • ↵3 This work was supported by the Canadian Institutes of Health Research (Grant MOP-130239), the Natural Sciences and Engineering Council of Canada (Grant DG-203061), the Quebec Pain Research Network, and the Louise and Alan Edwards Foundation. I.D. holds a Fonds de recherche du Québec–Santé (FRQS) doctoral studentship, and H.B. holds FRQS and Arthritis Society postdoctoral fellowships.

Funding

  • CIHR

    MOP-130239
  • Natural Sciences and Engineering Research Council of Canada

    DG-203061
  • Fonds de Recherche du Quebec - Sante; (Fonds de la recherche en sante du Quebec)

    501100000156
  • Arthritis Society of Canada

  • Quebec Pain Research Network

  • Louise and Alan Edwards Foundation

Other Version

  • previous version (February 25, 2016).
  • You are viewing the most recent version of this article.

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Feb 20162706
Mar 2016190120232
Apr 2016827347314
May 2016229383228
Jun 20167327999
Jul 20164118997
Aug 20163413467
Sep 20164016477
Oct 20165519389
Nov 20166819982
Dec 20164713658
Total 2016163121441349
Jan 20173515344
Feb 20173212043
Mar 20172818147
Apr 20175214873
May 20175812470
Jun 2017329861
Jul 20172810095
Aug 20174114570
Sep 201758170105
Oct 20175813682
Nov 20173614782
Dec 2017127416
Total 20174701596788
Jan 2018145614
Feb 2018275325
Mar 2018196528
Apr 2018557648
May 20184512516
Jun 2018239979
Jul 2018233811
Aug 2018155536
Sep 20181810417
Oct 20182717415
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Dec 20182218617
Total 20183161209315
Jan 20191116712
Feb 2019922112
Mar 201951767
Apr 20191014414
May 2019818516
Jun 2019718016
Jul 2019417213
Aug 201982587
Sep 201966212
Oct 201936613
Nov 201935022
Dec 20197587
Total 2019811739151
Jan 202069420
Feb 202036430
Mar 20202739
Apr 2020212215
May 202061758
Jun 202051259
Jul 202041755
Aug 2020512110
Sep 202031126
Oct 2020622315
Nov 2020217117
Dec 202022279
Total 2020461682153
Jan 2021415813
Feb 2021317215
Mar 2021513616
Apr 202151989
May 2021114611
Jun 2021314512
Jul 2021213523
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Sep 2021013819
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Total 2021371809190
Jan 2022513918
Feb 202249123
Mar 2022514819
Apr 202211308
May 2022513412
Jun 2022413217
Total 20222477497
Total2605109533043
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Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain
Ihab Daou, Hélène Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Philippe Séguéla
eNeuro 25 February 2016, 3 (1) ENEURO.0140-15.2016; DOI: 10.1523/ENEURO.0140-15.2016

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Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain
Ihab Daou, Hélène Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Philippe Séguéla
eNeuro 25 February 2016, 3 (1) ENEURO.0140-15.2016; DOI: 10.1523/ENEURO.0140-15.2016
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Keywords

  • allodynia
  • dorsal root ganglia
  • inflammation
  • neuropathy
  • optogenetics
  • spinal cord

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