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Research ArticleNew Research, Disorders of the Nervous System

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Ila P. Karve, Moses Zhang, Mark Habgood, Tony Frugier, Kate M. Brody, Maithili Sashindranath, C. Joakim Ek, Stephane Chappaz, Ben T. Kile, David Wright, Hong Wang, Leigh Johnston, Maria Daglas, Robert C. Ates, Robert L. Medcalf, Juliet M. Taylor and Peter J. Crack
eNeuro 4 February 2016, 3 (1) ENEURO.0128-15.2016; https://doi.org/10.1523/ENEURO.0128-15.2016
Ila P. Karve
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Moses Zhang
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Mark Habgood
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Tony Frugier
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Kate M. Brody
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Maithili Sashindranath
2Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia, 3004
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C. Joakim Ek
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Stephane Chappaz
3ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3052
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  • ORCID record for Stephane Chappaz
Ben T. Kile
3ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3052
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David Wright
4Florey Imaging, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 3052
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Hong Wang
4Florey Imaging, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 3052
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Leigh Johnston
4Florey Imaging, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 3052
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Maria Daglas
2Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia, 3004
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Robert C. Ates
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Robert L. Medcalf
2Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia, 3004
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Juliet M. Taylor
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Peter J. Crack
1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
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Article Information

DOI 
https://doi.org/10.1523/ENEURO.0128-15.2016
PubMed 
27022620
Published By 
Society for Neuroscience
History 
  • Received October 28, 2015
  • Revision received December 21, 2015
  • Accepted January 14, 2016
  • Published online February 4, 2016.
Copyright & Usage 
Copyright © 2016 Karve et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Ila P. Karve1,
  2. Moses Zhang1,
  3. Mark Habgood1,
  4. Tony Frugier1,
  5. Kate M. Brody1,
  6. Maithili Sashindranath2,
  7. C. Joakim Ek1,
  8. Stephane Chappaz3,
  9. Ben T. Kile3,
  10. David Wright4,
  11. Hong Wang4,
  12. Leigh Johnston4,
  13. Maria Daglas2,
  14. Robert C. Ates1,
  15. Robert L. Medcalf2,
  16. Juliet M. Taylor1 and
  17. Peter J. Crack1
  1. 1Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia, 3010
  2. 2Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia, 3004
  3. 3ACRF Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3052
  4. 4Florey Imaging, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 3052
  1. Correspondence should be addressed to Peter Crack, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia. E-mail: pcrack{at}unimelb.edu.au.
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Author contributions

  1. ↵2 Author contributions: I.P.K., M.Z., T.F., K.M.B., S.C., D.W., H.W., and P.J.C. performed research; I.P.K., T.F., M.S., C.J.E., S.C., D.W., M.D., J.M.T., and P.J.C. analyzed data; M.H., T.F., M.S., C.J.E., B.T.K., and P.J.C. contributed unpublished reagents/analytic tools; L.J., R.C.A., R.L.M., J.M.T., and P.J.C. designed research; I.P.K., J.M.T., and P.J.C. wrote the paper.

Disclosures

  • ↵1 The authors report no conflict of interest.

  • ↵3 This work was supported by National Health and Medical Research Council of Australia Project Grant 628391 (PJC) and Project Grant 1044714 (PJC, JMT), an Australian Research Council Future Fellowship (PJC) and the Rebecca Cooper Foundation.

Funding

  • Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)

    501100000925; APP1044714
  • Australian Research Council

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  • You are viewing the most recent version of this article.
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Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury
Ila P. Karve, Moses Zhang, Mark Habgood, Tony Frugier, Kate M. Brody, Maithili Sashindranath, C. Joakim Ek, Stephane Chappaz, Ben T. Kile, David Wright, Hong Wang, Leigh Johnston, Maria Daglas, Robert C. Ates, Robert L. Medcalf, Juliet M. Taylor, Peter J. Crack
eNeuro 4 February 2016, 3 (1) ENEURO.0128-15.2016; DOI: 10.1523/ENEURO.0128-15.2016

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Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury
Ila P. Karve, Moses Zhang, Mark Habgood, Tony Frugier, Kate M. Brody, Maithili Sashindranath, C. Joakim Ek, Stephane Chappaz, Ben T. Kile, David Wright, Hong Wang, Leigh Johnston, Maria Daglas, Robert C. Ates, Robert L. Medcalf, Juliet M. Taylor, Peter J. Crack
eNeuro 4 February 2016, 3 (1) ENEURO.0128-15.2016; DOI: 10.1523/ENEURO.0128-15.2016
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Keywords

  • neuroinflammation
  • traumatic brain injury
  • type-1 interferon

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