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History
- Received January 26, 2016
- Revision received February 11, 2016
- Accepted February 12, 2016
- Published online February 28, 2016.
Copyright & Usage
Copyright © 2016 Schwartz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Author Information
- Michael D. Schwartz1,
- Alexander T. Nguyen1,
- Deepti R. Warrier1,
- Jeremiah B. Palmerston1,
- Alexia M. Thomas1,
- Stephen R. Morairty1,
- Thomas C. Neylan2 and
- Thomas S. Kilduff1
- 1Biosciences Division, Center for Neuroscience, SRI International, Menlo Park, California 94025
- 2UCSF San Francisco VA Medical Center/NCIRE, San Francisco, California 94121
- Correspondence should be addressed to Dr Thomas S. Kilduff, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025. E-mail: thomas.kilduff{at}sri.com.
Author contributions
2 Author contributions: M.D.S., S.R.M., T.C.N., and T.S.K. designed research; M.D.S., A.T.N., D.R.W., J.B.P., and A.M.T. performed research; M.D.S., A.T.N., J.B.P., and A.M.T. analyzed data; M.D.S. and T.S.K. wrote the paper.
Disclosures
1 The authors report no conflict of interest.
3 This work was supported by the U.S. Army Medical Research Acquisition Activity award number W81XWH-09-2-0081 and NIH R01 NS077408 to T.S.K. We thank Drs Priyattam J. Shiromani and Carlos Blanco-Centurion for providing Hcrt2-SAP; Tsui-Ming Chen, Alan Wilk, and Dr Simon Fisher for technical assistance; Dr Ling Jong for synthesis of almorexant; and Drs Sarah Black and Gregory Parks for helpful comments on data analysis and the paper.
Funding
U.S. Army Medical Research Acquisition Activity
W81XWH-09-2-0081HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
NS077408
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